{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:57:49Z","timestamp":1791838669760,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Map\u2010like redness is a newly identified endoscopic risk factor for gastric cancer in patients who received <jats:italic>Helicobacter pylori<\/jats:italic> eradication therapy. However, the incidence rate of map\u2010like redness in patients who received eradication, and the risk factors for the development of map\u2010like redness remain unclear. We hence aimed to investigate the incidence rate of map\u2010like redness at 1\u2010year post <jats:italic>H.\u2009pylori<\/jats:italic> eradication, and evaluated its associations with map\u2010like redness and gastric cancer in relation with gastric condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Endoscopic severity of gastritis and map\u2010like redness were retrospectively evaluated according to the Kyoto Classification of Gastritis in patients who had undergone endoscopy before and after <jats:italic>H.\u2009pylori<\/jats:italic> eradication therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence rate of map\u2010like redness for all 328 patients at a mean of 1.2\u2009\u00b1\u20090.6\u2009years after eradication was 25.3% (95% confidence interval [CI]: 20.7%\u201330.4%). Patients who developed map\u2010like redness were older, had more severe atrophy and intestinal metaplasia, a higher total score of the Kyoto Classification of Gastritis both before and after eradication, and a higher rate of gastric cancer history than patients who did not have map\u2010like redness. On multivariate analysis, risk of map\u2010like redness was increased in patients with intestinal metaplasia (odds ratio [OR]: 2.794, 95% CI: 1.155\u20136.757) and taking acid inhibitors (OR: 1.948, 95% CI: 1.070\u20133.547). Characteristics of <jats:italic>H.\u2009pylori<\/jats:italic>\u2010positive patients with gastric cancer history were patients who were older (OR: 1.033, 95% CI: 1.001\u20131.066), taking acid inhibitors (OR: 4.456, 95% CI: 2.340\u20138.484), and with occurrence of map\u2010like redness after eradication therapy (OR: 2.432, 95% CI: 1.264\u20134.679).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Map\u2010like redness is observed in one fourth of patients at 1\u2010year post eradication. Patients who developed map\u2010like redness were found to have severe intestinal metaplasia and taking acid inhibitors, and hence such patients require increased attention at surveillance endoscopy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.13046","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T09:31:09Z","timestamp":1706088669000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Risk of map\u2010like redness development after eradication therapy for <i>Helicobacter pylori<\/i> infection"],"prefix":"10.1111","volume":"29","author":[{"given":"Sho","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University Hospital  Tokyo 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