{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T07:59:03Z","timestamp":1768031943370,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Helicobacter<\/jats:italic> species (spp.) have been detected in human bile and hepatobiliary tissue <jats:italic>Helicobacter<\/jats:italic> spp. promote gallstone formation and hepatobiliary tumors in laboratory studies, though it remains unclear whether <jats:italic>Helicobacter<\/jats:italic> spp. contribute to these cancers in humans. We used a multiplex panel to assess whether seropositivity to <jats:italic>Helicobacter (H.) hepaticus<\/jats:italic> or <jats:italic>H.\u2009bilis<\/jats:italic> proteins was associated with the development of hepatobiliary cancers in the Finnish Alpha\u2010Tocopherol, Beta\u2010Carotene Cancer Prevention (ATBC) Study, and US\u2010based Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 62 biliary and 121 liver cancers, and 190 age\u2010matched controls from ATBC and 74 biliary and 105 liver cancers, and 364 age\u2010 and sex\u2010matched controls from PLCO. Seropositivity to 14 <jats:italic>H.\u2009hepaticus<\/jats:italic> and <jats:italic>H.\u2009bilis<\/jats:italic> antigens was measured using a multiplex assay. Odds ratios (ORs) and 95% confidence intervals (CIs) were adjusted for major hepatobiliary cancer risk factors and <jats:italic>Helicobacter pylori<\/jats:italic> serostatus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seropositivity to the <jats:italic>H<\/jats:italic>.\u2009<jats:italic>bilis antigen,<\/jats:italic> P167D, was associated with more than a twofold higher risk of liver cancer (OR: 2.38; 95% CI: 1.06, 5.36) and seropositivity to the <jats:italic>H<\/jats:italic>.\u2009<jats:italic>hepaticus<\/jats:italic> antigens HH0407 or HH1201, or <jats:italic>H.\u2009bilis<\/jats:italic> antigen, HRAG 01470 were associated with higher risk of biliary cancer (OR: 5.01; 95% CI: 1.53, 16.40; OR: 2.40; 95% CI: 1.00, 5.76; OR: 3.27; 95% CI: 1.14, 9.34, respectively) within PLCO. No associations for any of the <jats:italic>H<\/jats:italic>.\u2009<jats:italic>hepaticus or H<\/jats:italic>.\u2009<jats:italic>bilis<\/jats:italic> antigens were noted for liver or biliary cancers within ATBC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Further investigations in cohort studies should examine the role of <jats:italic>Helicobacter<\/jats:italic> spp. in the etiology of liver and biliary cancers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.13053","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T07:29:26Z","timestamp":1707463766000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<i>Helicobacter hepaticus<\/i> and <i>Helicobacter bilis<\/i> in liver and biliary cancers from ATBC and PLCO"],"prefix":"10.1111","volume":"29","author":[{"given":"Gwen","family":"Murphy","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology &amp; Genetics National Cancer Institute, National Institutes of Health  Bethesda Maryland USA"},{"name":"Cancer Screening and Prevention Research Group (CSPRG), Department of Surgery and Cancer Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neal D.","family":"Freedman","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology &amp; Genetics National Cancer Institute, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian C.","family":"Abnet","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology &amp; Genetics National Cancer Institute, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demetrius","family":"Albanes","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology &amp; Genetics National Cancer Institute, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda J.","family":"Cross","sequence":"additional","affiliation":[{"name":"Cancer Screening and Prevention Research Group (CSPRG), Department of Surgery and Cancer Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Yi","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology &amp; Genetics National Cancer Institute, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill","family":"Koshiol","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology &amp; Genetics National Cancer Institute, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"McGlynn","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology &amp; Genetics National Cancer Institute, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominick","family":"Parisi","sequence":"additional","affiliation":[{"name":"Information Management Services, Inc.  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