{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:02:09Z","timestamp":1791061329739,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":35,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The amoxicillin dose used in dual therapy to eradicate <jats:italic>Helicobacter pylori<\/jats:italic> varies across studies and the optimal amoxicillin dose for vonoprazan\u2010based dual therapies remains unclear. We aimed to investigate the efficacy and safety of low\u2010 and high\u2010dose amoxicillin in vonoprazan\u2013amoxicillin dual therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A comprehensive systematic review was conducted by searching databases from inception to October 2023. All trials that evaluated the effectiveness and safety of vonoprazan\u2013amoxicillin dual therapy for eradicating <jats:italic>H.\u2009pylori<\/jats:italic> were included. Pooled eradication rate, incidence of adverse events, relative risks, and 95% confidence intervals are presented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen studies with 12 low\u2010dose amoxicillin (VLA) and 13 high\u2010dose amoxicillin (VHA) arms were included. The pooled eradication rates were 82.4% and 86.8% for VLA therapy, and 86.0% and 90.9% for VHA therapy by the intention\u2010to\u2010treat and per\u2010protocol analyses, respectively. In the subgroup analysis stratified by duration, the eradication rates achieved in 7\u2009days, 10\u2009days, and 14\u2009days treatments with VLA and VHA dual therapies were 80.8%, 84.2%, 83.1%, and 67.3%, 88.8%, 87.5%, respectively. In the four randomized controlled trials that directly compared VLA and VHA dual therapies, the efficacy was not statistically different in the intention\u2010to\u2010treat (76.9% vs 81.4%, <jats:italic>p<\/jats:italic>\u2009=\u20090.337) and per\u2010protocol (81.6% vs 84.0%, <jats:italic>p<\/jats:italic>\u2009=\u20090.166) analyses. Additionally, the incidence of adverse events (<jats:italic>p<\/jats:italic>\u2009=\u20090.965) and compliance (<jats:italic>p<\/jats:italic>\u2009=\u20090.994) were similar in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>VLA therapy demonstrated comparable efficacy and safety to VHA therapy, along with regional differences. An appropriately extended treatment duration may be critical for therapeutic optimization of vonoprazan\u2013amoxicillin treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.13054","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T08:07:36Z","timestamp":1707293256000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Low\u2010dose or high\u2010dose amoxicillin in vonoprazan\u2010based dual therapy for <i>Helicobacter pylori<\/i> eradication? A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"29","author":[{"given":"Kun\u2010Ping","family":"Ju","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing\u2010Zhou","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7042-9695","authenticated-orcid":false,"given":"Yue\u2010Yue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital of Shandong University  Jinan China"},{"name":"Shandong Provincial Clinical Research Center for digestive disease  Jinan China"},{"name":"Laboratory of Translational Gastroenterology Qilu Hospital of Shandong University  Jinan China"},{"name":"Robot 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