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However, the increasing prevalence of antibiotic resistance in <jats:italic>H. pylori<\/jats:italic> has prompted the search for alternative treatment options. Photodynamic therapy has emerged as a potential alternative therapy, thus offering the advantage of avoiding some of the side effects associated with antibiotics and effectively targeting drug\u2010resistant strains. In the postantibiotic era, photodynamic therapy (PDT) has shown promise as a novel treatment for <jats:italic>H. pylori<\/jats:italic> infection. This review focused on elucidating the mechanism of photodynamic therapy in the treatment of <jats:italic>H. pylori<\/jats:italic>. Additionally, we present an overview of the current research on photodynamic therapy by examining both standalone photodynamic therapy and combination therapies for <jats:italic>H. pylori<\/jats:italic> infection treatment. Furthermore, the safety profile of photodynamic therapy was also evaluated. 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