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Patients who cannot use amoxicillin pose a therapeutic challenge and necessitate alternative medications. Preliminary research indicates that cefuroxime demonstrates promising potential for eradicating <jats:italic>H. pylori<\/jats:italic> infection, and there is a lack of comprehensive review articles on the use of cefuroxime.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This study conducts a thorough systematic literature review and synthesis. A comprehensive systematic search was conducted in PubMed, Web of Science, EMBASE, China National Knowledge Infrastructure, China Biology Medicine disc, and Wanfang Data up to January 13, 2024. The search strategy utilized the following keywords: (Cefuroxime) AND (<jats:italic>Helicobacter pylori<\/jats:italic> OR <jats:italic>Helicobacter nemestrinae<\/jats:italic> OR <jats:italic>Campylobacter pylori<\/jats:italic> OR <jats:italic>Campylobacter pylori<\/jats:italic> subsp. <jats:italic>pylori<\/jats:italic> OR <jats:italic>Campylobacter pyloridis<\/jats:italic> OR <jats:italic>H. pylori<\/jats:italic> OR Hp) for both English and Chinese language publications. Sixteen studies from five different countries or regions were included in final literature review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analysis results indicate that <jats:italic>H. pylori<\/jats:italic> is sensitive to cefuroxime, with resistance rates similar to amoxicillin being relatively low. Regimens containing cefuroxime have shown favorable eradication rates, which were comparable to those of the regimens containing amoxicillin. Regarding safety, the incidence of adverse reactions in cefuroxime\u2010containing eradication regimens was comparable to that of amoxicillin\u2010containing regimens or other bismuth quadruple regimens, with no significant increase in allergic reactions in penicillin\u2010allergic patients. Regarding compliance, studies consistently report high compliance rates for regimens containing cefuroxime.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cefuroxime can serve as an alternative to amoxicillin for the patients allergic to penicillin with satisfactory efficacies, safety, and compliance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.13073","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T07:58:46Z","timestamp":1712822326000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Application of cefuroxime in the eradication therapy of <i>Helicobacter pylori<\/i> infection: A review article"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7844-1357","authenticated-orcid":false,"given":"Changmin","family":"Mi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Peking University Third 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