{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:35:40Z","timestamp":1791898540117,"version":"4.3.4"},"reference-count":65,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      This study aims to evaluate the efficacy and safety of vonoprazan\u2010amoxicillin (VA), vonoprazan\u2010amoxicillin\u2010clarithromycin (VAC), vonoprazan\u2010based bismuth\u2010containing quadruple therapy (VBQT), and PPI\u2010based triple (PAC) or quadruple therapy (PBQT) for\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection with the consideration of duration of therapy and amoxicillin dose (H: high; L: low).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>PubMed, Embase, and the Cochrane Central Register of Controlled Trials were searched for eligible randomized controlled trials (RCTs) up to December 15, 2023. The efficacy outcome was eradication rate, and safety outcomes included the rates of adverse events and treatment discontinuation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010seven RCTs were included. The pooled eradication rates were 82.8% for VA, 89.1% for VAC, and 91.8% for VBQT, which increased with the higher amoxicillin frequency of administration and extended duration of therapy within each regimen. There were no significant differences in eradication rate when comparing 7\u2010VA versus 7\u2010VAC and 14\u2010VA versus 14\u2010VAC. VA was at least comparable to PAC. The eradication rate did not differ significantly between 10\u2010H\u2010VA or 14\u2010H\u2010VA versus 14\u2010PBQT. 7\u2010L\u2010VAC demonstrated higher eradication rate versus 7\u2010PAC and comparable rate to 14\u2010PAC. 14\u2010VBQT showed higher eradication rates versus 14\u2010PBQT. The adverse events rate was 19.3% for VA, 30.6% for VAC, and 38.4% for VBQT. VA had similar risk of adverse events versus VAC and significantly fewer adverse events compared to PBQT. The treatment discontinuation rate did not differ significantly between treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The eradication rate of VBQT was the highest at above 90% followed by VAC and VA. VA was as effective as VAC and superior to PPI\u2010based therapies with favorable safety, highlighting the potential of VA therapy as a promising alternative to traditional PPI\u2010based therapies. VPZ\u2010based triple or quadruple therapies was more effective than PPI\u2010based therapies. Further studies are needed to establish the optimal treatment regimen especially in the western countries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.13094","type":"journal-article","created":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T00:19:44Z","timestamp":1716596384000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Vonoprazan\u2010based therapies versus PPI\u2010based therapies in patients with\n                    <i>H. pylori<\/i>\n                    infection: Systematic review and meta\u2010analyses of randomized controlled trials"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4848-3000","authenticated-orcid":false,"given":"Ligang","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Therapeutic Innovations and Outcomes (ITIO), College of Pharmacy The Ohio State University  Columbus Ohio 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