{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:02:56Z","timestamp":1791216176685,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Helicobacter pylori (H. pylori)<\/jats:italic>is a common bacterial infection which predominately drives upper gastrointestinal pathology. We carried out a nationwide serological survey in response to the deficiency of robust African data on<jats:italic>H. pylori<\/jats:italic>prevalence, age of acquisition, socio\u2010geographic determinants, and impact on gastric physiology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This was a cross\u2010sectional study of archival plasma samples collected during the Zambia Population\u2010based HIV impact Assessment (ZAMPHIA) 2016 survey. ZAMPHIA used a two\u2010stage door\u2010to\u2010door stratified cluster sample approach to collect samples from adults and children from age 0 to 59\u2009years (<jats:italic>n<\/jats:italic>\u2009=\u200924,266). We randomly retrieved one fifth of these samples from each of Zambia's 10 provinces and used ELISA to test for<jats:italic>H. pylori<\/jats:italic>IgG antibodies, pepsinogen 1 and 2 and gastrin\u201017. A pepsinogen 1:2 ratio of &lt;3 was used to define gastric atrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis of 4050 plasma samples (30% &lt;16\u2009years, 53% females) revealed an overall<jats:italic>H. pylori<\/jats:italic>seroprevalence of 79%. By the age of 10\u2009years, more than 75% of the children had<jats:italic>H. pylori<\/jats:italic>. Urban residence was associated with increased odds (OR 1.8, 95% CI 1.5\u20132.2,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and HIV infection was associated with reduced odds (OR 0.7, 95% CI 0.5\u20130.9,<jats:italic>p<\/jats:italic>\u2009=\u20090.02) of<jats:italic>H. pylori<\/jats:italic>seropositivity. Gastric atrophy was detected in 6% of<jats:italic>H. pylori<\/jats:italic>seropositive adults below 45\u2009years of age and 9% in those between 45 and 59\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We have confirmed a high prevalence of<jats:italic>H. pylori<\/jats:italic>seropositivity in Zambia, predominantly in urban settings. The prevalence of gastric atrophy is broadly consistent with other populations around the globe, but our sample did not include adults over 60\u2009years.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.13096","type":"journal-article","created":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T04:19:48Z","timestamp":1716610788000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Nationwide survey of<i>Helicobacter pylori<\/i>seropositivity and gastric atrophy in Zambia"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6521-2501","authenticated-orcid":false,"given":"Violet","family":"Kayamba","sequence":"first","affiliation":[{"name":"Tropical Gastroenterology and Nutrition Group Lusaka Zambia"},{"name":"University of Zambia School of Medicine Lusaka Zambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Husna","family":"Munshi","sequence":"additional","affiliation":[{"name":"Tropical Gastroenterology and Nutrition Group Lusaka Zambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutinta Nyama","family":"Hankolwe","sequence":"additional","affiliation":[{"name":"Tropical Gastroenterology and Nutrition Group Lusaka Zambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciluvya","family":"Kaluba\u00a0Kavimba","sequence":"additional","affiliation":[{"name":"Tropical Gastroenterology and Nutrition Group Lusaka Zambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gershom","family":"Chongwe","sequence":"additional","affiliation":[{"name":"Tropical Diseases Research Centre Ndola Zambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria","family":"Knaze","sequence":"additional","affiliation":[{"name":"Early Detection, Prevention, and Infections Branch International Agency for Research on Cancer (IARC\/WHO) Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Young","family":"Park","sequence":"additional","affiliation":[{"name":"Early Detection, Prevention, and Infections Branch International Agency for Research on Cancer (IARC\/WHO) Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Kelly","sequence":"additional","affiliation":[{"name":"Tropical Gastroenterology and Nutrition Group Lusaka Zambia"},{"name":"University of Zambia School of Medicine Lusaka Zambia"},{"name":"Blizard Institute, Barts &amp; The London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.12.022"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.5230\/jgc.2024.24.e10"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.04.022"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00431-8"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1999.61.37"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200012050-00002"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.4.429"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2009.00368.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.4.1323-1327.2001"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4314\/ahs.v23i1.46"},{"issue":"3","key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.25100\/cm.v44i3.1263","article-title":"Gastric c\u00e1ncer: overview","volume":"44","author":"Piazuelo MB","year":"2013","journal-title":"Colomb Med (Cali)"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.06.078"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.46046"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184272"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142080"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2005.01.016"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2010.4.3.307"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043290"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000065"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2011.645501"},{"key":"e_1_2_11_22_1","unstructured":"Zambia Ministry of Health.Zambia Population\u2010Based HIV Impact Assessment (ZAMPHIA). 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