{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:36:59Z","timestamp":1792100219952,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T00:00:00Z","timestamp":1717891200000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Potassium\u2010competitive acid blockers have demonstrated enormous potential in the eradication treatment of\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      infection, with tegoprazan being one of the representatives. The available data on the safety and efficacy of tegoprazan in dual therapy are limited.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      The multicenter, noninferiority, randomized\u2010controlled trial was conducted from May 2023 to March 2024. Treatment\u2010naive subjects were randomly assigned (1:1) to enter either the tegoprazan\u2013amoxicillin (TA) group (tegoprazan 50\u2009mg twice daily and amoxicillin 750\u2009mg four times daily) or the esomeprazole\u2013amoxicillin (EA) group (esomeprazole 20\u2009mg and amoxicillin 750\u2009mg\u2009all four times daily), with a duration for 14\u2009days. The primary outcome was eradication rate as determined by\n                      <jats:sup>13<\/jats:sup>\n                      C\u2010urea breath test, including per\u2010protocol (PP) analysis and intention\u2010to\u2010treat (ITT) analysis. Secondary outcomes were adverse events and compliance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 368 individuals were included in the randomization. The eradication rates in the EA group and the TA group were 84.2% and 85.8%, respectively, according to an ITT analysis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.77), and 88.5% and 88.2%, respectively, according to PP analysis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.00). The eradication rates for the TA group were not inferior to those of the EA group in both PP (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0023) and ITT analyses (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0009). There were no significant statistical differences in the incidence of adverse events and compliance between the two groups. The multivariate logistic regression analysis revealed that poor compliance increased the risk of eradication failure (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dual therapy containing tegoprazan is safe and effective to be considered as a clinical first\u2010line treatment option, but further optimization involving antimicrobial susceptibility testing and adjustments in dosage and frequency is warranted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      ID: NCT05870683.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.13098","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T01:10:45Z","timestamp":1717981845000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Fourteen\u2010Day Tegoprazan\u2013Amoxicillin Dual Therapy as the First\u2010Line Treatment of\n                    <i>Helicobacter pylori<\/i>\n                    Infection (\n                    <scp>SHARE2301<\/scp>\n                    ): A Multicenter, Noninferiority, Randomized Clinical Trial"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4744-3269","authenticated-orcid":false,"given":"Qingzhou","family":"Kong","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong China"},{"name":"Laboratory of Translational Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong China"},{"name":"Shandong Provincial Clinical Research Center for Digestive Disease Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iqtida\u00a0Ahmed","family":"Mirza","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong China"},{"name":"Laboratory of Translational Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong China"},{"name":"Shandong Provincial Clinical Research Center for Digestive Disease Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shandong Second Medical University Affiliated Hospital  Weifang Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The People's Hospital of Jimo  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital of Shandong University Dezhou Hospital  Dezhou Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiumei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Traditional Chinese Medicine Hospital of Yuncheng County  Heze Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Zhengzhou Central Hospital Affiliated to Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Affiliated Hospital of Qingdao University  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9556-8771","authenticated-orcid":false,"given":"Xiuli","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong China"},{"name":"Laboratory of Translational Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong China"},{"name":"Shandong Provincial Clinical Research Center for 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