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The aim of the study was to assess the impact of indications for\n                      <jats:italic>H.\u2009pylori<\/jats:italic>\n                      investigation on prescriptions, effectiveness, compliance, and tolerance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      International, prospective, non\u2010interventional registry of the management of\n                      <jats:italic>H.\u2009pylori<\/jats:italic>\n                      infection by European gastroenterologists (Hp\u2010EuReg). Treatment\u2010n\u00e4ive patients registered from 2013 to 2023 at e\u2010CRF AEG\u2010REDCap were analyzed. The effectiveness was assessed by modified intention\u2010to\u2010treat analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 53,636 treatment\u2010na\u00efve cases from 34 countries were included. Most frequent indications were: dyspepsia with normal endoscopy (49%), non\u2010investigated dyspepsia (20%), duodenal ulcer (11%), gastric ulcer (7.7%), and gastroesophageal reflux disease (GERD) (2.6%). Therapy effectiveness varied by indication: duodenal ulcer (91%), gastric ulcer (90%), preneoplastic lesions (90%), dyspepsia with normal endoscopy (89%), GERD (88%), and non\u2010investigated dyspepsia (87%). Bismuth\u2010metronidazole\u2010tetracycline and clarithromycin\u2010amoxicillin\u2010bismuth quadruple therapies achieved 90% effectiveness in all indications except GERD. Concomitant clarithromycin\u2010amoxicillin\u2010tinidazole\/metronidazole reached 90% cure rates except in patients with non\u2010investigated dyspepsia; whereas sequential clarithromycin\u2010amoxicillin\u2010tinidazole\/metronidazole proved optimal (\u226590%) in patients with gastric ulcer only. Adverse events were higher in patients treated for dyspepsia with normal endoscopy and duodenal ulcer compared with the remaining indications (23% and 28%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Therapeutic compliance was higher in patients with duodenal ulcer and preneoplastic lesions (98% and 99%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In Europe, patients with gastric or duodenal ulcers and preneoplastic lesions showed higher\n                      <jats:italic>H.\u2009pylori<\/jats:italic>\n                      treatment effectiveness. Bismuth and non\u2010bismuth quadruple therapies achieved optimal results in almost all indications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov identifier: NCT02328131.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.13111","type":"journal-article","created":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T02:35:29Z","timestamp":1720838129000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Indications of\n                    <i>Helicobacter pylori<\/i>\n                    Eradication Treatment and Its Influence on Prescriptions and Effectiveness (Hp\u2010\n                    <scp>EuReg<\/scp>\n                    )"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0857-8117","authenticated-orcid":false,"given":"Samuel\u00a0J.","family":"Mart\u00ednez\u2010Dom\u00ednguez","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Hospital Cl\u00ednico Universitario Lozano Blesa  Zaragoza Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n (IIS Arag\u00f3n), Facultad de Medicina Universidad de Zaragoza  Zaragoza Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Digestivas y Hep\u00e1ticas (CIBERehd)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga\u00a0P.","family":"Nyssen","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS\u2010Princesa), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Hospital Universitario de La Princesa Universidad Aut\u00f3noma de Madrid (UAM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Lanas","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Cl\u00ednico Universitario Lozano Blesa  Zaragoza Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n (IIS Arag\u00f3n), Facultad de Medicina Universidad de Zaragoza  Zaragoza Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Digestivas y Hep\u00e1ticas (CIBERehd)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Alfaro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Cl\u00ednico Universitario Lozano Blesa  Zaragoza Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n (IIS Arag\u00f3n), Facultad de Medicina Universidad de Zaragoza  Zaragoza Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Digestivas y Hep\u00e1ticas (CIBERehd)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laimas","family":"Jonaitis","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Lithuanian University of Health Sciences  Kaunas Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umud","family":"Mahmudov","sequence":"additional","affiliation":[{"name":"Modern Hospital  Baku Azerbaijan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Voynovan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology A.S. 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