{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:43:37Z","timestamp":1783691017944,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T00:00:00Z","timestamp":1722124800000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Data regarding\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      (\n                      <jats:italic>H. pylori<\/jats:italic>\n                      )\u2010associated mucosa\u2010associated lymphoid tissue (MALT) lymphoma in children are lacking. We aimed to characterize the diagnosis, management, and outcome of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2010associated MALT lymphoma in pediatric patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>\n                      A retrospective multicenter case series of the pediatric patients with\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2010associated MALT lymphoma who were diagnosed during 2010\u20132022.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five children, of them three females, were identified. The mean age at diagnosis was 14.6\u2009\u00b1\u20092.4\u2009years. The clinical presentation included abdominal pain (5\/5), nausea (3\/5), weight loss, night sweats, recurrent fever (1\/5), and iron deficiency anemia (2\/5). Endoscopic findings in both the stomach antrum and body included a fragile and hyperemic mucosa, large ulcers, extensive nodularity, and exudate. All the biopsies from the gastric mucosa were consistent with MALT lymphoma, and positive for\n                      <jats:italic>H. pylori<\/jats:italic>\n                      (by Giemsa stain). All the patients received triple therapy (amoxicillin, nitroimidazole, or a macrolide, and a proton pump inhibitor, for 14\u2009days), and achieved\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication. All had complete resolution of histological findings at the last follow\u2010up. In one patient, the histology of MALT lymphoma persisted 12\u2009months after\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication, and only the 18\u2010month\u2010biopsy was free of residual disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this series of pediatric MALT lymphoma, complete resolution of disease occurred in all the patients, yet histological remission was delayed in one. This supports the importance of endoscopic follow\u2010up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.13113","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:14:54Z","timestamp":1722212094000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<i>Helicobacter pylori<\/i>\n                    \u2010Associated Extranodal Marginal Zone Lymphoma of Mucosa\u2010Associated Tissue in Children: A Multicenter Case Series"],"prefix":"10.1111","volume":"29","author":[{"given":"Pesah","family":"Melnik","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology and Nutrition Unit Edmond and Lily Safra Children's Hospital, Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilana","family":"Weintraub","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Nutrition Unit Edmond and Lily Safra Children's Hospital, Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein","family":"Shamaly","sequence":"additional","affiliation":[{"name":"French Hospital  Nazareth Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomi","family":"Cohen","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit Dana\u2010Dwek Children's Hospital, Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noa","family":"Greenberg\u2010Kushnir","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Pediatric Oncology Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginette","family":"Schiby","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Pathology Chaim Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Batia","family":"Weiss","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Nutrition Unit Edmond and Lily Safra Children's Hospital, Sheba Medical Center  Tel Hashomer Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880018.2020.1779884"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13855"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.03.083"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcle.2018.09.009"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.25122\/jml\u20102018\u20100035"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016\u20105085(95)90408\u20105"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i16.2625"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478\u2010200304000\u201000014"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887\u2010019\u20101431\u20109"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins9040132"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864\u2010019\u20100687\u20105"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2019.10.010"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.07.005"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001594"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1703"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182227e90"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.13113","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hel.13113","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.13113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:49:33Z","timestamp":1772963373000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hel.13113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/hel.13113"],"URL":"https:\/\/doi.org\/10.1111\/hel.13113","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2024-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13113"}}