{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:54:53Z","timestamp":1782842093415,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":31,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970497"],"award-info":[{"award-number":["81970497"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170578"],"award-info":[{"award-number":["82170578"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2024,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n The effect of preprandial or postprandial administration of amoxicillin on the efficacy of vonoprazan\u2013amoxicillin dual therapy (VA\u2010dual therapy) for\n Helicobacter pylori<\/jats:italic>\n treatment has not been studied. It is also unclear whether amoxicillin dosing four times daily is more effective than three times daily. We aimed to investigate the effect of different amoxicillin administration regimens on the efficacy of VA\u2010dual therapy.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n H.\u2009pylori<\/jats:italic>\n \u2010infected subjects were randomly assigned to three groups in a 1:1:1 ratio to receive a 14\u2010day dual therapy consisting of vonoprazan 20\u2009mg twice daily + amoxicillin 1000\u2009mg three times daily before meals (BM\u2010TID) or 1000\u2009mg three times daily after meals (AM\u2010TID) or 750\u2009mg four times daily after meals (AM\u2010QID).\n H.\u2009pylori<\/jats:italic>\n eradication rates, adverse events rates, compliance, and antibiotic resistance were compared.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Between May 2021 to April 2023, 327 subjects were enrolled. The eradication rates of BM\u2010TID, AM\u2010TID, and AM\u2010QID dual therapy were 88.1%, 89.9%, and 93.6% in intention\u2010to\u2010treat (ITT) analysis, 90.6%, 94.2%, and 99.0% in modified ITT (MITT) analysis, and 90.4%, 94.1%, and 99.0% in per\u2010protocol (PP) analysis. Although there was non\u2010inferiority between BM\u2010TID and AM\u2010TID, as well as between AM\u2010TID and AM\u2010QID, AM\u2010QID was significantly more effective than BM\u2010TID. There were no significant differences in adverse event rates, compliance, and antibiotic resistance among the three groups.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Postprandial administration and the increased frequency of administration of amoxicillin may contribute to a better efficacy of VA\u2010dual therapy, especially for rescue therapy. All VA\u2010dual therapy in our study could achieve good efficacy for first\u2010line treatment.<\/jats:p>\n \n Trial Registration:<\/jats:bold>\n clinicaltrials.gov<\/jats:ext-link>\n : NCT05901051.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/hel.13118","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T09:55:21Z","timestamp":1722506121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Vonoprazan\u2013Amoxicillin Dual Therapy With Different Amoxicillin Administration Regimens for\n Helicobacter pylori<\/i>\n Treatment: A Randomized Controlled Trial"],"prefix":"10.1111","volume":"29","author":[{"given":"Shuhan","family":"Qiu","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Digestive Diseases, Division of Gastroenterology and Hepatology Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 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