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Despite the use of antibiotic therapy, the global prevalence of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection remains high, necessitating early eradication measures. Immunotherapy, especially vaccine development, is a promising solution in this direction, albeit the selection of an appropriate animal model is critical in efficient vaccine production. Accordingly, we conducted a literature, search and summarized the commonly used\n                    <jats:italic>H. pylori<\/jats:italic>\n                    strains,\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection\u2010related animal models, and models for evaluating\n                    <jats:italic>H. pylori<\/jats:italic>\n                    vaccines. Based on factors such as the ability to replicate human diseases, strain compatibility, vaccine types, and eliciting of immune responses, we systematically compared the advantages and disadvantages of different animal models, to obtain the informed recommendations. In addition, we have proposed novel perspectives on\n                    <jats:italic>H. pylori<\/jats:italic>\n                    \u2013related animal models to advance research and vaccine evaluation for the prevention and treatment of diseases such as gastric cancer.\n                  <\/jats:p>","DOI":"10.1111\/hel.13119","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T03:57:05Z","timestamp":1723003025000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Animal Models of\n                    <i>Helicobacter pylori<\/i>\n                    Infection and Vaccines: Current Status and Future Prospects"],"prefix":"10.1111","volume":"29","author":[{"given":"Zhili","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University  Nanchang China"},{"name":"HuanKui Academy Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8950-6133","authenticated-orcid":false,"given":"Qiong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002693"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12335"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/hel.12405","article-title":"Pathogenesis of Helicobacter pylori Infection","volume":"22","author":"Camilo 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