{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:16:51Z","timestamp":1790695011100,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":37,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      There is an economic evaluation on the family\u2010based\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      screen\u2010and\u2010treat strategy (FBHS) in China. This study aimed to compare the cost\u2010effectiveness of the FBHS with the traditional\n                      <jats:italic>H. pylori<\/jats:italic>\n                      screen\u2010and\u2010treat strategy (TBHS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      A seven\u2010state microsimulation model, including\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection and gastric cancer states, was constructed on the basis of the target family samples from 29 provinces in China. Taking a lifetime horizon from a healthcare system perspective, the long\u2010term costs and health outcomes of the FBHS and TBHS screening strategies were simulated separately, and economic evaluations were performed. The model parameters were primarily derived from real\u2010world data, published literature, and expert opinions. The primary outcome was the incremental cost\u2010effectiveness ratio (ICER) expressed as cost\/quality\u2010adjusted life\u2010year (QALY) gained. One\u2010way sensitivity analysis, probabilistic sensitivity analysis, and scenario analysis were performed to assess the uncertainty of the results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The base\u2010case analysis revealed that the average costs for FBHS and TBHS were 563.67 CNY and 574.08 CNY, respectively, with corresponding average QALYs of 14.83 and 14.79. The ICER for the comparison between the two strategies was \u2212214.07, indicating that FBHS was an absolutely dominant strategy with better cost\u2010effectiveness. The results of both one\u2010way sensitivity analysis and probabilistic sensitivity analysis were robust. When taking into account the added benefit of the higher\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication rate in FBHS, the average costs were further reduced, and the average QALYs were increased, solidifying its position as an unequivocally dominant strategy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The FBHS is an absolutely dominant and cost\u2010effective strategy that enables an optimized allocation of screening resources. Decision\u2010makers should prioritize FBHS when developing\n                      <jats:italic>H. pylori<\/jats:italic>\n                      prevention and control strategies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.13123","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T04:08:17Z","timestamp":1723003697000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["An Economic Evaluation of Family\u2010Based Versus Traditional\n                    <i>Helicobacter pylori<\/i>\n                    Screen\u2010and\u2010Treat Strategy: Based on Real\u2010World Data and Microsimulation Model"],"prefix":"10.1111","volume":"29","author":[{"given":"Yue","family":"Ma","sequence":"first","affiliation":[{"name":"School of International Pharmaceutical Business China Pharmaceutical University  Nanjing China"},{"name":"Center for Pharmacoeconomics and Outcomes Research China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianzhu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Changhai Hospital, Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashi","family":"Liu","sequence":"additional","affiliation":[{"name":"School of International Pharmaceutical Business China Pharmaceutical University  Nanjing China"},{"name":"Center for Pharmacoeconomics and Outcomes Research China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Changhai Hospital, Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aixia","family":"Ma","sequence":"additional","affiliation":[{"name":"School of International Pharmaceutical Business China Pharmaceutical University  Nanjing China"},{"name":"Center for Pharmacoeconomics and Outcomes Research China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4261-6888","authenticated-orcid":false,"given":"Yiqi","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Changhai Hospital, Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongchao","family":"Li","sequence":"additional","affiliation":[{"name":"School of International Pharmaceutical Business China Pharmaceutical University  Nanjing China"},{"name":"Center for Pharmacoeconomics and Outcomes Research China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91816-6"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10050-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)91028-6"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)80013-3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13911"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12597"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.51821\/86.1.11327"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.080507-0"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200207000-00014"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199002083220603"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.39.5.634"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-008-0699-8"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i10.995"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000000146"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-328965"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.05.023"},{"key":"e_1_2_10_18_1","first-page":"931","article-title":"Application of Microsimulation Models in Cost\u2010Effectiveness Analyses of Epidemiological Screening","volume":"06","author":"Liu Q. 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