{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:40:15Z","timestamp":1792597215558,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"vor","delay-in-days":50,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100030680","name":"Fu Jen Catholic University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030680","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Vonoprazan, a potassium\u2010competitive acid blocker, has demonstrated greater potency and a longer duration of acid suppression when compared to the proton pump inhibitors. However, data regarding the comparison between vonoprazan\u2010based triple therapy with standard treatment for first\u2010line\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      treatment are limited. This study aimed to compare the efficacy between 7\u2010day vonoprazan\u2010based triple therapy with high\u2010dose amoxicillin (VAC\u20107) and 14\u2010day extended sequential therapy (S\u201014).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      This was a single\u2010center prospective randomized controlled trial following a noninferiority design. Subjects over 20\u2009years old with confirmed\n                      <jats:italic>H<\/jats:italic>\n                      .\n                      <jats:italic>pylori<\/jats:italic>\n                      infection were enrolled prospectively from Fu Jen Catholic University Hospital. They were randomly assigned to the VAC\u20107 or S\u201014 group. The primary endpoint was the eradication rate in first\u2010line treatment, evaluated by urea breath test, with noninferiority determined using the Farrington\u2013Manning method. The secondary outcome included adverse effect rates and compliance, assessed through self\u2010administered questionnaires.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between December 2021 and June 2023, a total of 628 patients were recruited. The eradication rates by per\u2010protocol analysis and intention\u2010to\u2010treat analysis were 88.6%\/81.8% for VAC\u20107 and 90.3%\/81.4% for S\u201014, respectively. The VAC\u20107 was non\u2010inferior to S\u201014 in terms of ITT analysis. Subjects experienced fewer incidences of nausea, anorexia, dizziness, fatigue, and any severe adverse events in the VAC\u20107 group. Compliance was higher in the VAC\u20107 group, with 94% taking all the pills correctly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our findings supported the use of 7\u2010day vonoprazan triple therapy with high\u2010dose amoxicillin as the standard first\u2010line treatment for\n                      <jats:italic>H.\u2009pylori<\/jats:italic>\n                      infection.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\/\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT05371249\n                    <\/jats:p>\n                  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