{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:09:45Z","timestamp":1778695785301,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the efficacy of colloidal bismuth subcitrate (CBS) therapy for the eradication of <jats:italic>H. pylori<\/jats:italic> in patients from a national pediatric registry of <jats:italic>H. pylori<\/jats:italic> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Spanish Registry of Children with <jats:italic>H. pylori<\/jats:italic> Infection (RENIHp) is a national, multi\u2010center, prospective, non\u2010interventional registry that includes children aged 5\u201318\u2009years with <jats:italic>H. pylori<\/jats:italic> infection diagnosed by endoscopy. All patients in the registry who were treated with CBS between the period 2020 and 2023 were included in this study. The primary outcome was the eradication rate, which was assessed using a <jats:sup>13<\/jats:sup>C\u2010urea breath test or monoclonal antigen in the stool 6\u20138\u2009weeks post\u2010treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The registry included 682 patients, 38 (5.6%) of whom underwent treatment with CBS. Fifty percent (19\/38) of patients had previously undergone unsuccessful eradication treatment. In 78.9% (30\/38) of patients, treatment was guided by an antibiotic sensitivity test. In the remaining patients, an empirical approach was employed. The CBS therapies used were as follows: quadruple therapy with proton pump inhibitors (PPIs), CBS, amoxicillin, and metronidazole (MET) [18\/38 (47.3%)]; quadruple therapy with PPIs, CBS, tetracycline, and MET [13\/38 (34.2%)]; and other therapies [7\/38 (18.4%)]. Thirty\u2010two patients (84.2%) treated with CBS were followed\u2010up with eradication monitoring. The overall eradication rate in patients treated with CBS was 93.8% (30\/32, [95% CI: 85.4%\u2013100%]), whereas it was 86.7% in patients in the registry who were not on CBS treatment (430\/496, [95% CI: 83.3%\u201389.5%], <jats:italic>p<\/jats:italic>\u2009=\u20090.208). In the six patients with dual resistance to clarithromycin (CLA) and MET who were treated with quadruple therapy with CBS, the eradication rate was 100% (<jats:italic>n<\/jats:italic>\u2009=\u20096\/6, [95% CI: 61.0%\u2013100%]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CBS therapies in our registry, although only used in selected cases and at lower than recommended levels, were very effective and showed an eradication rate of &gt;\u200990%.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.13142","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T13:48:22Z","timestamp":1728568102000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy of Bismuth Therapy in Eradicating <i>Helicobacter pylori<\/i> in Children\u2014Data From the <scp>RENIHp<\/scp> Registry"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8865-1961","authenticated-orcid":false,"given":"Gonzalo","family":"Botija","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology Unit Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonzalo","family":"Galicia","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit Hospital Universitario de Guadalajara  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit Hospital Universitario de Fuenlabrada  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Cuadrado","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit Hospital Universitario Virgen Macarena  Sevilla Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Soria","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit Hospital Universitario HM Montepr\u00edncipe  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit Hospital Universitario Severo Ochoa, Legan\u00e9s  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Urruzuno","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit Hospital Universitario 12 de octubre  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda\u2010Luz","family":"Cilleruelo","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit Hospital Universitario Puerta de Hierro, Majadahonda  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"SEGHNP H. pylori Working Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001594"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0000000000000389"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28155921"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2mt00180b"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13346"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2010.131"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-311019"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2011.00863.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05055.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0547-9"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.5223\/pghn.2012.15.4.237"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12679"},{"issue":"6","key":"e_1_2_9_14_1","first-page":"1121","article-title":"Helicobacter pylori Eradication Efficacy of Therapy Based on the Antimicrobial Susceptibility in Children With Gastritis and Peptic Ulcer in Mekong Delta, Vietnam","volume":"10","author":"Le L. 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