{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:40:15Z","timestamp":1789000815499,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":51,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Treatment with potassium\u2010competitive acid blockers has shown acceptable efficacy in <jats:italic>Helicobacter pylori<\/jats:italic> eradication. In regions like Korea, where the clarithromycin resistance rate is high, alternative combinations like non\u2010bismuth quadruple therapies have shown favorable results. This study compared the outcomes of sequential eradication therapy with new potassium\u2010competitive acid blocker tegoprazan and conventional esomeprazole\u2010containing sequential therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Patients with <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) infection were consecutively recruited. Patients were allocated to either an esomeprazole\u2010containing sequential or a tegoprazan\u2010containing sequential therapy group. Sequential therapy comprised esomeprazole (40\u2009mg) or tegoprazan (50\u2009mg) plus amoxicillin (1000\u2009mg) twice daily for the initial 5\u2009days, followed by esomeprazole (40\u2009mg) or tegoprazan (50\u2009mg) with clarithromycin (500\u2009mg) and metronidazole (500\u2009mg) twice daily for the remaining 5\u2009days. Eradication rate, compliance, and adverse events were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 406 patients with <jats:italic>H. pylori<\/jats:italic> infection were enrolled in the trial and analyzed per protocol. Eradication rate by intention\u2010to\u2010treat and per\u2010protocol was 83.8% (95% confidence interval [CI]: 78.7\u201388.9) for esomeprazole\u2010containing sequential therapy, and 87.1% (95% CI: 82.5\u201391.8) for tegoprazan\u2010containing sequential therapy, with no statistical significance (<jats:italic>p<\/jats:italic>\u2009=\u20090.399). Additionally, there was no statistically significant difference in treatment compliance between the two groups. Nausea was more prevalent (23.3%, 27\/202) with sequential tegoprazans than with esomeprazole\u2010containing sequential therapy (14.2%, 29\/204; <jats:italic>p<\/jats:italic>\u2009=\u20090.022).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Tegoprazan\u2010containing 10\u2010day sequential eradication treatment demonstrated similar eradication efficacy compared to esomeprazole\u2010containing treatment, even in regions with high antimicrobial resistance, such as Korea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>: NCT06382493<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.13143","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T07:22:06Z","timestamp":1729581726000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Efficacy of Tegoprazan\u2010Containing Sequential Eradication Treatment Compared to Esomeprazole\u2010Containing Sequential Eradication of <i>Helicobacter pylori<\/i> in South Korea, a Region With High Antimicrobial Resistance: A\u00a0Prospective, Randomized, Single Tertiary Center Study"],"prefix":"10.1111","volume":"29","author":[{"given":"Jung\u00a0Won","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Samsung Changwon Hospital Sungkyunkwan University School of Medicine  Changwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9397-0406","authenticated-orcid":false,"given":"Nayoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital  Seongnam South Korea"},{"name":"Research Center for Sex\u2010 and Gender\u2010Specific Medicine Seoul National University Bundang Hospital  Seongnam South Korea"},{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongchan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital  Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So\u00a0Young","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital  Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u00a0Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital  Seongnam South Korea"},{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327745"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0132-6"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.03.028"},{"key":"e_1_2_10_5_1","first-page":"243","article-title":"Mass Eradication of Helicobacter pylori to Reduce Gastric Cancer Incidence and Mortality: A Long\u2010Term Cohort Study on Matsu Islands","volume":"70","author":"Chiang T. 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