{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T15:03:04Z","timestamp":1782831784416,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,11,3]],"date-time":"2024-11-03T00:00:00Z","timestamp":1730592000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018254","name":"Japanese Foundation for Research and Promotion of Endoscopy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018254","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Map\u2010like redness, pathological intestinal metaplasia, is observed in one\u2010fourth to one\u2010third of patients 1\u2009year after <jats:italic>Helicobacter pylori<\/jats:italic> eradication therapy, mainly in the corpus, and is a newly identified endoscopic risk factor for gastric cancer development after eradication. However, it is unclear whether intestinal metaplasia is present before eradication at the site where the map\u2010like redness appears. We aimed to identify endoscopic findings that predict the occurrence of map\u2010like redness before <jats:italic>H. pylori<\/jats:italic> eradication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>As a prospective multicenter trial, the characteristics of patients in whom map\u2010like redness developed after eradication, and the association between the endoscopic severity of gastritis and the development of map\u2010like redness in patients who underwent endoscopy before and 1\u2010year after eradication were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The rate of map\u2010like redness in all 93 patients 1\u2010year postsuccessful eradication was 30.1% (95% confidence interval [CI]: 21.0\u201340.5). All patients with map\u2010like redness were endoscopically observed to have intestinal metaplasia before eradication, in the site that subsequently developed map\u2010like redness. Patients who developed map\u2010like redness were older, had more severe intestinal metaplasia and nodularity and a higher total score on the Kyoto Classification of Gastritis both before and after eradication than patients who did not. On multivariate analysis, map\u2010like redness was found to be associated with posttreatment intestinal metaplasia (odds ratio: 8.144; 95% CI: 2.811\u201323.592).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In all patients who developed map\u2010like redness after eradication, endoscopic intestinal metaplasia was observed at the site developed map\u2010like redness before eradication therapy. Map\u2010like redness was especially observed in patients with more severe intestinal metaplasia at 1\u2010year after eradication. Such patients require increased attention at surveillance endoscopy, owing to generally having a higher risk of gastric cancer development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.umin.ac.jp\/ctr\/index.htm\">University Hospital Medical Information Network<\/jats:ext-link>: UMIN000044707<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.13146","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T05:06:57Z","timestamp":1730696817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Map\u2010Like Redness Development After Eradication Therapy for <i>Helicobacter pylori<\/i> Infection: Prospective Multicenter Observational Study"],"prefix":"10.1111","volume":"29","author":[{"given":"Sho","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University Hospital  Shinjuku\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9194-7392","authenticated-orcid":false,"given":"Mitsushige","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Division of Genome\u2010Wide Infectious Microbiology, Research Center for GLOBAL and LOCAL Infectious Diseases Oita University  Oita Yufu Japan"},{"name":"Department of Gastroenterological Endoscopy Tokyo Medical University Hospital  Shinjuku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Terai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Fujieda Municipal General Hospital  Fujieda Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0269-7799","authenticated-orcid":false,"given":"Yasuhiko","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Fujieda Municipal General Hospital  Fujieda Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3325-8414","authenticated-orcid":false,"given":"Shu","family":"Sahara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hamamatsu Medical Center  Hamamatsu Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Kanaoka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hamamatsu Medical Center  Hamamatsu Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashiro","family":"Yoshizawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Seirei Hamamatsu General Hospital  Hamamatsu Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Unno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Seirei Hamamatsu General Hospital  Hamamatsu Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4951-0584","authenticated-orcid":false,"given":"Masaki","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology National Hospital Organization Kyoto Medical Center  Kyoto Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Uotani","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Japanese Red Cross Shizuoka Hospital  Shizuoka Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Japanese Red Cross Shizuoka Hospital  Shizuoka Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1386-0985","authenticated-orcid":false,"given":"Shigemi","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Japan Community Healthcare Organization Shiga Hospital  Otsu Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoyuki","family":"Hayafuji","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Japan Community Healthcare Organization Shiga Hospital  Otsu Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Haruma","sequence":"additional","affiliation":[{"name":"General Internal Medicine 2 Kawasaki Medical School General Medical Center  Okayama Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoari","family":"Kamada","sequence":"additional","affiliation":[{"name":"Department of Health Care Medicine Kawasaki Medical School General Medical Center  Okayama Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakatsu","family":"Fukuzawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University Hospital  Shinjuku\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Endoscopy Tokyo Medical University Hospital  Shinjuku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Itoi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University Hospital  Shinjuku\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2001.00042.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12415"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i15.1820"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-019-01639-w"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000487045"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.56.7775"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13540"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000501534"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13486"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.13046"},{"issue":"5","key":"e_1_2_9_13_1","first-page":"203","article-title":"Predictability of Gastric Intestinal Metaplasia by Mottled Patchy Erythema Seen on Endoscopy","volume":"4","author":"Nagata N.","year":"2011","journal-title":"Gastroenterology Research"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2019.06.043"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12581"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2023.2231852"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1272187"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.16324"},{"issue":"6","key":"e_1_2_9_19_1","first-page":"982","article-title":"Helicobacter pylori Infection and Endoscopic Gastritis\u2014Kyoto Classification of Gastritis","volume":"112","author":"Kamada T.","year":"2015","journal-title":"Nihon Shokakibyo Gakkai Zasshi"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1098086"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.14114"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-020-01375-z"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-944632"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489454"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.7326\/M19-2561"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5054237"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2022.2063372"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2020.1868567"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70019-2"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.13146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T03:08:06Z","timestamp":1735528086000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hel.13146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/hel.13146"],"URL":"https:\/\/doi.org\/10.1111\/hel.13146","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2024-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13146"}}