{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:00:40Z","timestamp":1792479640603,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":55,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NO.82072253"],"award-info":[{"award-number":["NO.82072253"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Vonoprazan is a novel potassium\u2010competitive acid blocker (P\u2010CAB) that offers several advantages, such as fast onset time and strong acid inhibition, in the treatment of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Helicobacter pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection. This study aims to evaluate the efficacy, adverse reactions, and compliance of the 14\u2010day vonoprazan\u2010amoxicillin dual therapy versus drug sensitivity\u2010based individualized therapy in the retreatment of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This multicenter, open\u2010label, randomized, controlled non\u2010inferiority study enrolled 240 adult patients who previously failed anti\u2010\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      treatment. These patients were randomly assigned to receive the 14\u2010day vonoprazan\u2010amoxicillin dual therapy or drug sensitivity\u2010based individualized therapy. The primary outcome was the eradication rate, and the secondary outcomes mainly included adverse events, patient compliance, antibiotic resistance rates, and risk factors that affected the eradication rate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The intention\u2010to\u2010treat (ITT) and per\u2010protocol (PP) analyses revealed that the eradication rates for the vonoprazan\u2010amoxicillin dual therapy and drug sensitivity\u2010based individualized therapy were comparably high, with rates of 87.50% and 83.33%, respectively. Furthermore, the vonoprazan\u2010amoxicillin dual therapy fulfilled the criteria for the non\u2010inferiority test, when compared to individualized therapy. The incidence of adverse reactions was significantly lower in the vonoprazan\u2010amoxicillin dual therapy group. Both groups showed similarly good compliance and comparable rates of antibiotic resistance. The previous treatment with a clarithromycin\u2010containing regimen was identified as an independent risk factor for clarithromycin resistance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The 14\u2010day vonoprazan\u2010amoxicillin dual therapy exhibits high eradication rates and low incidence of adverse reactions in retreated patients, indicating its effectiveness and safety as a rescue regimen for patients with\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.70009","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T11:20:17Z","timestamp":1741605617000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Vonoprazan\u2010Amoxicillin Dual Therapy Versus Drug Sensitivity\u2010Based Individualized Therapy as a Rescue Regimen for\n                    <i>Helicobacter pylori<\/i>\n                    Infection: A Multicenter, Randomized Controlled Trial"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4869-2136","authenticated-orcid":false,"given":"Yu\u2010xiang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital Army Medical University (Third Military Medical University)  Chongqing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han\u2010ning","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital Army Medical University (Third Military Medical University)  Chongqing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng\u2010qi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital Army Medical University (Third Military Medical University)  Chongqing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010ying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital Army Medical University (Third Military Medical University)  Chongqing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010li","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital Army Medical University (Third Military Medical University)  Chongqing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010lin","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology West District Hospital of Chongqing  Chongqing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010jing","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The 13th People's Hospital of Chongqing  Chongqing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital Army Medical University (Third Military Medical University)  Chongqing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing\u2010wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Daping Hospital Army Medical University (Third Military Medical University)  Chongqing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital Army Medical University (Third Military Medical University)  Chongqing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010hui","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital Army Medical University (Third Military Medical University)  Chongqing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0924\u20108579(00)00320\u20104"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/cm9.0000000000002546"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102022\u2010327745"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.4238\/gmr.15038674"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12584"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756284820976990"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1128497"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i34.5097"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756284820968736"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15575"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102015\u2010311019"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz046"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.10.036"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12596"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010010\u20100220\u2010x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13588"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2015.18"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13414"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102015\u2010311304"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000502287"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12970"},{"key":"e_1_2_7_23_1","unstructured":"\u201cCommon Terminology Criteria for Adverse Events (CTCAE). Dept. of Health and Human Services National Institutes of Health \u201d National Cancer Institute 2010."},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.04.022"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562848221145566"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102019\u2010319954"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11010116"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-199910000-00001"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00053"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102015\u2010310376"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky530"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ137"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.2217\/14622416.7.6.831"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs\u20102021\u20100083"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.70009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:13Z","timestamp":1741824013000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hel.70009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/hel.70009"],"URL":"https:\/\/doi.org\/10.1111\/hel.70009","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70009"}}