{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:56:22Z","timestamp":1792497382502,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2025,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n As the antibiotic resistance and treatment failure rates of\n \n Helicobacter pylori<\/jats:italic>\n <\/jats:styled-content>\n are rising, the need for rescue therapy with rifabutin for\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n eradication (HPE) is also increasing. Therefore, in this study, we investigated the efficacy, resistance status, and adverse events in patients receiving rifabutin\u2010based HPE.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n Between January 2020 and December 2022, 3006 patients underwent esophagogastroduodenoscopy (EGD) with\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n culture tests. Of these, culture results were successfully obtained from 1792 patients, who were subsequently enrolled in our study. The medical records of these patients were retrospectively reviewed, and their clinical features and outcomes assessed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among the 1792 patients, 14 (0.8%) were rifabutin\u2010resistant. A total of 665 (37.1%) patients had multidrug\u2010resistant (MDR)\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n infections. Patients with rifabutin\u2010resistant\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n infections had a significantly higher rate of tuberculosis treatment history (2.8% vs. 28.6%,\n p<\/jats:italic>\n \u2009<\u20090.001) and MDR\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n infections (49.6% vs. 85.7%,\n p<\/jats:italic>\n \u2009<\u20090.001) than those in the rifabutin\u2010susceptible\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n group. Among the 45 patients who received the rifabutin\u2010based HPE regimen, 44 (97.8%) had MDR\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n infection, and 35 (77.8%) underwent rifabutin\u2010based HPE as a third\u2010line treatment or beyond. A total of 31 (68.9%) showed successful eradication. Nineteen (42.2%) patients experienced at least one symptom of adverse events; however, the severity of side effects was mild, and no patient discontinued treatment because of this.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The rifabutin\u2010based HPE regimen could be an effective and safe treatment method. It is particularly considered a viable therapeutic option for patients who require HPE but have previously failed to respond to multiple HPEs.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/hel.70011","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T07:13:41Z","timestamp":1738653221000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Efficacy of Rifabutin\u2010Based\n Helicobacter pylori<\/i>\n Eradication Regimen in Korea With High Prevalence of Tuberculosis Infection"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4372-065X","authenticated-orcid":false,"given":"Yuri","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Keimyung University Dongsan Hospital, Keimyung University School of Medicine Daegu South 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Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0030-3744","authenticated-orcid":false,"given":"Ji Yong","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center University of Ulsan College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4250-4683","authenticated-orcid":false,"given":"Do Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center University of Ulsan College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2517-4109","authenticated-orcid":false,"given":"Kee Don","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center University of Ulsan College of Medicine Seoul South 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