{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:48:39Z","timestamp":1791514119486,"version":"4.3.4"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":58,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1604174"],"award-info":[{"award-number":["U1604174"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>Helicobacter pylori<\/jats:italic><\/jats:styled-content> (<jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content>) is the major cause of gastric mucosal precancerous lesions in adulthood, but its impact on pediatric patients remains unclear. We aimed to investigate <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content>\u2010induced gastric precancerous lesions in children and adolescents globally and analyze their influencing factors for related disease management and prevention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We conducted a comprehensive literature search in major databases to identify studies including pediatric patients with gastric precancerous lesions and <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> infection status. Prevalence rates were computed using random\u2010effects or fixed\u2010effect models. A stratified analysis was conducted based on location, age, universal health coverage (UHC), and publication time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 3359 relevant articles screened, 24 studies (7036 participants) met the inclusion criteria. The overall prevalence of precancerous lesions in <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content>\u2010infected patients was 17.2%, in which atrophic gastritis (AG) and intestinal metaplasia (IM) were 13.5% and 3.6%, respectively. Precancerous lesion rates in infected individuals across different regions\u00a0were as follows: Africa at 33.8% (AG: 32.6%), Latin America at 22.1% (AG: 17.9%, IM: 4.0%), Asia at 18.1% (AG: 12.4%, IM: 4.4%, Dysplasia: 1.2%), and Europe at 6.3% (AG: 4.3%, IM: 1.7%). Infected adolescents (&gt;\u200910\u2009years) exhibited a higher prevalence of precancerous lesions than younger children (\u2264\u200910\u2009years) at 14.2% (AG: 9.7%, IM: 2.9%) versus 3.4% (AG: 2.3%, IM: 1.1%), respectively. The prevalence of precancerous lesions in infected patients was higher in areas with low\u2010medium UHC compared with high UHC (24.0% vs. 12.5%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> infection causes significant gastric mucosal precancerous lesions in pediatric patients, representing a major concern for this population and a previously neglected area. Future in\u2010depth investigations and proper management for related disease prevention are warranted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>\u00a0PROSPERO number: CRD42023424683<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.70021","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T02:16:06Z","timestamp":1741745766000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Global Prevalence of <i>Helicobacter pylori<\/i> Infection\u2010Associated Gastric Preneoplastic Lesions in Pediatric Patients: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3286-8368","authenticated-orcid":false,"given":"Mohammed Awadh","family":"Abdun","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology People's Hospital of Zhengzhou University and Henan Provincial People's Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3212-6009","authenticated-orcid":false,"given":"Lu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology People's Hospital of Zhengzhou University and Henan Provincial People's Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9200-6084","authenticated-orcid":false,"given":"Xiao\u2010Ting","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology People's Hospital of Zhengzhou University and Henan Provincial People's Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9105-5198","authenticated-orcid":false,"given":"Amr","family":"Mekky","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology People's Hospital of Zhengzhou University and Henan Provincial People's Hospital  Zhengzhou Henan China"},{"name":"Reference Laboratory (RLQP) Animal Health Research Institute, Agriculture Research Center (ARC)  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9814-8051","authenticated-orcid":false,"given":"Maher","family":"Al Hussan","sequence":"additional","affiliation":[{"name":"Hepatobiliary Pancreatic Surgery The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8445-8152","authenticated-orcid":false,"given":"Ezaldin M. 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