{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T07:23:53Z","timestamp":1763277833403,"version":"3.41.2"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":40,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>Helicobacter pylori<\/jats:italic><\/jats:styled-content> infection is one of the most prevalent chronic bacterial infections worldwide. This bacillus colonizes the human stomach lifelong, where it induces chronic gastritis, evolving in some cases to gastro\u2010duodenal ulcers, gastric adenocarcinoma, and mucosa\u2010associated lymphoid tissue lymphoma. <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u2009pylori<\/jats:italic><\/jats:styled-content> infection has also been associated with extragastric diseases, and clinical data have suggested a role in liver pathogenesis. This retrospective study evaluated the consequences of chronic infection with gastric <jats:italic>Helicobacters<\/jats:italic> on liver pathogenesis in a mouse experimental model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>C57BL6 mice were infected with either <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u2009felis<\/jats:italic><\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u2009=\u200912) or five human and mouse\u2010adapted strains of <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u2009pylori<\/jats:italic><\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u2009=\u200977) for one year. Uninfected mice were used as negative controls (<jats:italic>n<\/jats:italic>\u2009=\u200910). Histopathological analysis of paraffin\u2010embedded liver tissue sections was performed, and scores were determined in a double\u2010blind manner for inflammation and steatosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mice infected with <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u2009felis<\/jats:italic><\/jats:styled-content> and several <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u2009pylori<\/jats:italic><\/jats:styled-content> strains developed more liver parenchymal inflammation and steatosis, known precursor lesions of liver carcinogenesis, compared to non\u2010infected mice. The presence of liver lesions was positively correlated with the detection of lesions of the gastric mucosa, more particularly gastric inflammation and metaplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chronic infection of mice with <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u2009felis<\/jats:italic><\/jats:styled-content> and <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u2009pylori<\/jats:italic><\/jats:styled-content> induces liver pathogenesis characterized by parenchymal inflammation and steatosis, which may be associated with the severity of gastric histopathological lesions. Understanding <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u2009pylori<\/jats:italic><\/jats:styled-content> infection's impact on extragastric lesions could <jats:italic>in fine<\/jats:italic> help detect and prevent the emergence of other digestive tract\u2010related diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.70032","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T11:53:42Z","timestamp":1744286022000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chronic Infection With Gastric <i>Helicobacters<\/i> Induces Hepatic Lesions in Mice"],"prefix":"10.1111","volume":"30","author":[{"given":"Lornella","family":"Seeneevassen","sequence":"first","affiliation":[{"name":"INSERM U1312, Bordeaux Institute of Oncology University of Bordeaux  Bordeaux 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