{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T23:15:44Z","timestamp":1792278944623,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"vor","delay-in-days":48,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hainan Province","doi-asserted-by":"publisher","award":["823QN372"],"award-info":[{"award-number":["823QN372"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hainan Province","doi-asserted-by":"publisher","award":["821RC736"],"award-info":[{"award-number":["821RC736"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2025,3]]},"abstract":"ABSTRACT<\/jats:title>Background<\/jats:title>High\u2010Dose Dual Therapy With Amoxicillin Has Shown Advantages to Eradicate Helicobacter pylori<\/jats:italic><\/jats:styled-content> (H. pylori<\/jats:italic><\/jats:styled-content>), but Not for Penicillin\u2010Allergic Patients. It Is Recommended That Cefuroxime Could Be an Alternative, but Whether Cefuroxime Could Be Used in Dual Therapy Has Not Been Reported. This Study Aimed to Compare the Efficacy, Safety, and Compliance of Cefuroxime\u2010Based Dual Therapy (CDT<\/jats:styled-content>) With Cefuroxime\u2010Based Bismuth Quadruple Therapy (CQT<\/jats:styled-content>) to Treat H. pylori<\/jats:italic><\/jats:styled-content> Infection.<\/jats:p><\/jats:sec>Materials and Methods<\/jats:title>The Prospective, Multicenter, Open\u2010Label, Randomized Controlled Trial Was Conducted to Enroll Patients With Treatment\u2010Naive H. pylori<\/jats:italic><\/jats:styled-content> Infection From 9 Institutions. Patients Were Randomly Assigned to CDT<\/jats:styled-content> Group (Cefuroxime 500\u2009Mg Three Times\/Day and Vonoprazan 20\u2009Mg Twice\/Day) or CQT<\/jats:styled-content> Group (Cefuroxime 500\u2009Mg Twice\/Day, Levofloxacin 500\u2009Mg Once\/Day, Vonoprazan 20\u2009Mg Twice\/Day, and Bismuth 220\u2009Mg Twice\/Day), both for 14\u2009Days.<\/jats:p><\/jats:sec>Results<\/jats:title>700 Patients (350 per Group) Were Enrolled. In the Intention\u2010To\u2010Treat Analysis, Eradication Rates Were 76.0% and 86.3% in CDT<\/jats:styled-content> Group and CQT<\/jats:styled-content> Group (P<\/jats:italic>\u2009=\u20090.001). In the Modified Intention\u2010To\u2010Treat Analysis, Eradication Rates Were 78.9% and 89.1% (P<\/jats:italic>\u2009<\u20090.001). In the Per\u2010Protocol Analysis, Eradication Rates Were 80.2% and 91.2% (P<\/jats:italic>\u2009<\u20090.001). The Incidence of Adverse Events Was Significantly Lower in CDT<\/jats:styled-content> Group Than CQT<\/jats:styled-content> Group (14.4% vs. 29.8%, P<\/jats:italic>\u2009<\u20090.001). Non\u2010inferiority Was Confirmed Between CDT<\/jats:styled-content> and CQT<\/jats:styled-content> Group (All P<\/jats:italic>\u2009>\u20090.025). Compliance Was Good in Both Groups (96.0% vs. 92.8%, P<\/jats:italic>\u2009=\u20090.073). Poor Adherence Was a Risk Factor for Reducing the Efficacy in Both Groups.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>CQT<\/jats:styled-content> Was More Effective Than CDT<\/jats:styled-content> for H. pylori<\/jats:italic><\/jats:styled-content> Eradication, Which Might Be Recommended for Penicillin\u2010Allergic Patients. If There Were Contraindications or Intolerance of CQT<\/jats:styled-content>, CDT<\/jats:styled-content> Would Be an Alternative.<\/jats:p><\/jats:sec>Trail Registration<\/jats:title>ChiCTR2300071210<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.70037","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T05:16:18Z","timestamp":1745817378000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of Cefuroxime\u2010Based Dual Therapy With Quadruple Therapy in Helicobacter pylori<\/i>\u2010Infected Treatment\u2010Naive Patients: A Prospective, Multicenter, Randomized Controlled Trial"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0057-6575","authenticated-orcid":false,"given":"Ji\u2010Yan","family":"Li","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Tongji Hospital, Tongji Medical College, Huazhong University of Science 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