{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:22:54Z","timestamp":1792009374026,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T00:00:00Z","timestamp":1751760000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HA23C0266"],"award-info":[{"award-number":["HA23C0266"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>Helicobacter pylori<\/jats:italic><\/jats:styled-content> eradication reduces gastric cancer risk, but the long\u2010term impact in peptic ulcer patients, particularly those with gastric ulcers (GU), remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the long\u2010term incidence of gastric cancer in patients with <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content>\u2010treated gastric ulcers compared to the general population and to patients with duodenal ulcers (DU).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using Korea's National Health Insurance Service database, we identified patients aged \u2265\u200940\u2009years with endoscopically and histologically confirmed peptic ulcers treated for <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> between 2005 and 2008. Follow\u2010up continued until 2019. Standardized incidence ratios (SIRs) for gastric cancer were calculated by comparing incidence in the study cohorts with the age\u2010 and sex\u2010matched general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 166,260 eligible patients (median follow\u2010up 9.2\u2009years), 2630 (1.58%) developed gastric cancer (SIR, 1.20; 95% CI, 1.15\u20131.24; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), with consistently elevated risks across all age groups. Although cancer incidence remained elevated up to 12\u2009years, patients followed for \u2265\u200913\u2009years exhibited a significantly reduced risk compared to the general population (SIR, 0.78; 95% CI, 0.60\u20130.99; <jats:italic>p<\/jats:italic>\u2009=\u20090.049). In a sensitivity analysis, duodenal ulcer patients (<jats:italic>n<\/jats:italic>\u2009=\u200946,602) showed a lower overall risk (SIR, 0.86; 95% CI, 0.78\u20130.94; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), with significant reductions even before 13\u2009years of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Gastric ulcer patients remain at increased risk for gastric cancer following <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> treatment. However, this risk declines over time and may fall below that of the general population after 13\u2009years. These findings support the need for long\u2010term surveillance in this high\u2010risk group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.70057","type":"journal-article","created":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T23:26:31Z","timestamp":1751844391000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010Term Risk of Gastric Cancer After <scp><i>Helicobacter pylori<\/i><\/scp> Eradication in Gastric Ulcer Patients: A Nationwide Cohort Study in Korea"],"prefix":"10.1111","volume":"30","author":[{"given":"Seokho","family":"Myeong","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Seoul St. Mary's Hospital, College of Medicine, the Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7278-2174","authenticated-orcid":false,"given":"Donghoon","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul St. Mary's Hospital, College of Medicine, the Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9158-1012","authenticated-orcid":false,"given":"Joon Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Incheon St. Mary's Hospital, College of Medicine, the Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Kyung","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul St. Mary's Hospital, College of Medicine, the Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon Woo","family":"Yim","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1534-7467","authenticated-orcid":false,"given":"Jae Myung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul St. Mary's Hospital, College of Medicine, the Catholic University of Korea  Seoul Korea"},{"name":"Department of Medical Life Sciences The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.04.022"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708423"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.05.027"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l5016"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.03.039"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05314.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.05.023"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-116-9-705"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199607253350404"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41384.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.07.060"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.08.033"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.1138_a.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.12.022"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002484"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2019.138"},{"issue":"3","key":"e_1_2_11_19_1","first-page":"275","article-title":"Diagnosis and Treatment of Helicobacter Pylori Infection in Korea","volume":"32","author":"Korean H. pylori Study Group","year":"1998","journal-title":"Korean Journal of Gastroenterology"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg052"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.03.028"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/epirev\/mxaf007"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.04.019"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12646"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12780"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl240489"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00431-8"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.12.270"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.70057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T04:24:30Z","timestamp":1756787070000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hel.70057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/hel.70057"],"URL":"https:\/\/doi.org\/10.1111\/hel.70057","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70057"}}