{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T01:25:49Z","timestamp":1787966749555,"version":"build-2784847793"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":43,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470593"],"award-info":[{"award-number":["82470593"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A 10\u2009day vonoprazan\u2013amoxicillin (VA) regimen (amoxicillin 750\u2009mg four times daily) achieved &gt;\u200990% <jats:styled-content style=\"fixed-case\"><jats:italic>Helicobacter pylori (H. pylori)<\/jats:italic><\/jats:styled-content> eradication rates in the initial treatment. Whether less frequent dosing or shorter duration provides comparable efficacy remains unclear. This study aimed to evaluate the efficacy of simplified 7 or 10\u2010day VA regimens to determine the optimal first\u2010line strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this multicenter, randomized, open\u2010label, non\u2010inferiority trial, treatment\u2010naive <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content>\u2010positive patients were randomly assigned (1:1:1:1) to four treatment groups: VA\u2010T7 (amoxicillin 1000\u2009mg three times daily for 7\u2009days), VA\u2010Q7 (amoxicillin 750\u2009mg four times daily for 7\u2009days), VA\u2010T10 (amoxicillin 1000\u2009mg three times daily for 10\u2009days), and VA\u2010Q10 (amoxicillin 750\u2009mg four times daily for 10\u2009days). All the patients received vonoprazan 20\u2009mg twice daily. The primary outcome was the eradication rate. The secondary outcomes included adverse events and adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 500 patients were enrolled. The eradication rates of the VA\u2010T7, VA\u2010Q7, VA\u2010T10, and VA\u2010Q10 groups were 84.0%, 81.6%, 91.2%, and 90.4% by intention\u2010to\u2010treat (ITT) analysis; 86.8%, 83.6%, 92.7%, and 92.6% by modified intention\u2010to\u2010treat (mITT) analysis; 88.2%, 85.7%, 93.4%, and 94.1% by per\u2010protocol (PP) analysis, respectively. The efficacy of VA\u2010T10 was non\u2010inferior to that of VA\u2010Q10 (<jats:italic>p<\/jats:italic>\u2009=\u20090.002; <jats:italic>p<\/jats:italic>\u2009=\u20090.001; <jats:italic>p<\/jats:italic>\u2009=\u20090.002 in the ITT, mITT and PP analyses, respectively). Both 7\u2010day regimens failed to meet the non\u2010inferiority margin of \u221210%. No significant effect of dosing frequency on eradication rates was observed. Adverse events and adherence were comparable among the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The VA\u2010T10 regimen is effective, well\u2010tolerated, and suitable for first\u2010line <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> eradication, whereas 7\u2010day regimens are not recommended due to eradication rates &lt;\u200990%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link> identifier: ChiCTR2400079754 (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.chictr.org.cn\">www.chictr.org.cn<\/jats:ext-link>)<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.70062","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T03:46:20Z","timestamp":1755143180000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Optimizing Duration and Dosing Frequency of Vonoprazan\u2013Amoxicillin Dual Therapy for <i>Helicobacter pylori<\/i>: A Multicenter Randomized Trial"],"prefix":"10.1111","volume":"30","author":[{"given":"Lulong","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital with Nanjing Medical University  Nanjing Jiansgsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5329-0182","authenticated-orcid":false,"given":"Haisheng","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of 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