{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:15:46Z","timestamp":1789503346695,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":49,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170578"],"award-info":[{"award-number":["82170578"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970497"],"award-info":[{"award-number":["81970497"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Autoimmune gastritis (AIG) is a chronic immune\u2010mediated disease characterized by the presence of anti\u2010parietal cell antibody and progressive corpus\u2010predominant atrophy. The global prevalence of AIG and its associated factors remain poorly understood. This study aimed to systematically estimate the prevalence of AIG worldwide and identify demographic and diagnostic factors influencing its variability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this systematic review and meta\u2010analysis, we searched Medline, Scopus, and Embase from database inception until December 7, 2024. Prevalence was pooled using a random\u2010effects model, and potential sources of heterogeneity were explored by subgroup analysis and meta\u2010regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 47 studies involving 15,817 individuals were included. The global prevalence of AIG was estimated at 3.85% (95% CI: 2.94\u20135.04, <jats:italic>I<\/jats:italic><jats:sup><jats:italic>2<\/jats:italic><\/jats:sup>\u2009=\u200999.3%). Notable geographical variation was observed, with a prevalence of 4.94% in Europe (95% CI: 3.66\u20136.63), 2.23% in Asia (95% CI: 1.19\u20134.14), 2.82% in America (95% CI: 1.48\u20135.31), 8.46% in Africa (95% CI: 5.58\u201313.14) and 8.08% in Australia (95% CI: 4.69\u201312.79). The prevalence was highest when diagnosed by serological antibody (5.4%, 95% CI: 3.79\u20137.65), followed by histology (2.71%, 95% CI: 1.68\u20134.36) and combined serology and histology (1.81%, 95% CI: 0.80\u20134.07). Meta\u2010regression analysis revealed a positive correlation between <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> infection and AIG prevalence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study estimated the global prevalence of AIG and underscored the significant geographical and methodological variability. Future studies of large\u2010scale are still in urgent need to standardize the diagnostic criteria and further investigate risk factors, thus enhancing the understanding and management of AIG.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.70065","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T04:16:22Z","timestamp":1755663382000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Prevalence of Autoimmune Gastritis Worldwide: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"30","author":[{"given":"Meixuan","family":"Li","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai Institute of Digestive Disease  Shanghai 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