{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T01:25:49Z","timestamp":1787966749795,"version":"build-2784847793"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The optimal duration for vonoprazan and amoxicillin dual therapy (VA\u2010DT) remains unclear, and studies on gastric acid suppression of vonoprazan during eradication are still lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study conducted a multicenter, randomized controlled trial to compare the eradication efficacy between 10 and 14\u2010day VA\u2010DT, and to identify the dynamic changes of gastric pH during treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study included 418 na\u00efve adult patients with\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Helicobacter pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection, who were randomly divided into 10 or 14\u2010day VA\u2010DT groups (vonoprazan 20\u2009mg twice daily and amoxicillin 1000\u2009mg thrice daily).\n                      <jats:sup>13<\/jats:sup>\n                      C\u2010urea breath tests were conducted at 4\u20138\u2009weeks after eradication to evaluate the success of treatment. 24\u2010h intragastric pH was monitored in 22 patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ten and 14\u2010day VA\u2010DT demonstrated eradication rates of 83.3% vs. 88.0% (rate difference: \u22124.8%, 95% confidence interval: \u221211.6% to \u22122.0%) in intention\u2010to\u2010treat analysis, 87.9% vs. 93.9% (\u22126.0%, \u221211.9% to \u22120.3%) in modified intention\u2010to\u2010treat analysis, and 89.1% vs. 95.3% (\u22126.1%, \u221211.8% to \u22120.7%) in per\u2010protocol analysis, respectively. Vonoprazan showed excellent gastric acid suppression during eradication, with the time percentages of pH &gt;\u20096 at 75.3% and 97.2% and the median pH levels at 7.4 and 7.8 on the 1st and 7th days, respectively. Furthermore, gastric pH exceeded 6 approximately 4\u20135\u2009h after the first dose and remained stable at 7\u20139 thereafter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The noninferiority of eradication efficacy between 10\u2010 and 14\u2010day VA\u2010DT in the first\u2010line treatment was not established, indicating that 10\u2010day therapy cannot be used as a substitute for 14\u2010day therapy. Vonoprazan exerted excellent gastric acid suppression during eradication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Chinese Clinical Trial Registry: ChiCTR2200057625<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.70070","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T04:55:47Z","timestamp":1757048147000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Ten\u2010Day Versus 14\u2010Day Vonoprazan and Amoxicillin Dual Therapy for the Firstline Eradication of\n                    <scp>\n                      <i>Helicobacter pylori<\/i>\n                    <\/scp>\n                    Infection: A Multicenter, Randomized Controlled 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