{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:14:27Z","timestamp":1790633667747,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>In countries with an intermediate incidence of gastric cancer (GC), it has been suggested that offering an upper gastrointestinal endoscopy (UGIE) to individuals referred for a screening colonoscopy following a positive result in the fecal immunochemical test (FIT) may be cost\u2010effective. This study was designed to evaluate the impact of a FIT\u2010based screening program on GC incidence, early diagnosis, and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Population\u2010based retrospective cohort study in northern Portugal. Data on GC cases were retrieved from the Portuguese National Cancer Registry (RON). GC stage at diagnosis (with early stages defined as T1) and net survival estimates were compared between 2014 and 2016 and the first 3\u2009years of the FIT\u2010based screening program (2018\u20132020), during which 165,967 tests were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The odds of GC detection were significantly higher among FIT\u2010positive individuals compared to those with a negative result (OR\u2009=\u20092.87; 95% CI: 1.76\u20134.49). Of the 10,372 individuals who completed FIT screening and underwent colonoscopy, 51% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095281) also underwent UGIE. The proportion of early\u2010stage diagnoses increased by 14% (95% CI: 12\u201315), and 3\u2010year net survival improved from 42% (95% CI: 40\u201343) to 48% (95% CI: 47\u201350).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Despite the absence of a formal GC screening program, more than half of FIT\u2010screened individuals who underwent colonoscopy also underwent UGIE. The period following the implementation of FIT\u2010based screening was associated with increased early\u2010stage detection and improved survival. These findings support the potential value of offering UGIE combined with colonoscopy for FIT\u2010positive individuals, at least in regions with intermediate GC incidence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.70071","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T04:33:50Z","timestamp":1757738030000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of a\n                    <scp>FIT<\/scp>\n                    Based Colorectal Cancer Screening Program on Gastric Cancer Incidence, Early Diagnosis and Patients' Survival"],"prefix":"10.1111","volume":"30","author":[{"given":"Jo\u00e3o Carlos","family":"Silva","sequence":"first","affiliation":[{"name":"Gastroenterology Department Unidade Local de Sa\u00fade Gaia e Espinho (ULSGE)  Vila Nova de Gaia Portugal"},{"name":"MEDCIDS Faculty of Medicine, University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Leite\u2010Silva","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Portuguese Oncology Institute of Porto (IPO Porto)  Porto Portugal"},{"name":"Group of Epidemiology, Results, Economy and Management in Oncology IPO Porto Research Center (CI\u2010IPOP), Portuguese Oncology Institute of Porto (IPO Porto)  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Tavares","sequence":"additional","affiliation":[{"name":"National Screening Coordinator Center \u2010 Portuguese National Health Service Executive Board  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jos\u00e9","family":"Bento","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Portuguese Oncology Institute of Porto (IPO Porto)  Porto Portugal"},{"name":"Group of Epidemiology, Results, Economy and Management in Oncology IPO Porto Research Center (CI\u2010IPOP), Portuguese Oncology Institute of Porto (IPO Porto)  Porto Portugal"},{"name":"Population Studies Department, School of Medicine and Biomedical Sciences, ICBAS University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo","family":"Lib\u00e2nio","sequence":"additional","affiliation":[{"name":"Gastroenterology Department and PreCAM, RISE@CI\u2010IPOP (Health Research Network) Portuguese Oncology Institute of Porto (IPO Porto) &amp; Porto Comprehensive Cancer Centre (Porto.CCC)  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rio","family":"Dinis\u2010Ribeiro","sequence":"additional","affiliation":[{"name":"MEDCIDS Faculty of Medicine, University of Porto  Porto Portugal"},{"name":"Gastroenterology Department and PreCAM, RISE@CI\u2010IPOP (Health Research Network) Portuguese Oncology Institute of Porto (IPO Porto) &amp; Porto Comprehensive Cancer Centre (Porto.CCC)  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.12.027"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2023.02.013"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9072172"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640617722902"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000002680"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1104-5245"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2529-5025"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12150"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-333029"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000065"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2024.04.028"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1673-1118"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.20344\/amp.15904"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_2_9_17_1","volume-title":"The ICD\u201010 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines","author":"WHO","year":"1992"},{"key":"e_1_2_9_18_1","first-page":"1456","volume-title":"Cancer Incidence in Five Continents","author":"Waterhouse J. A. H.","year":"1976"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19980430)17:8<873::AID-SIM779>3.0.CO;2-I"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-0420.2011.01640.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.07.002"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-113128"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.13135"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000002671"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-332705"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12548"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4376-8"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1513011"},{"key":"e_1_2_9_29_1","volume-title":"Population\u2010Based Helicobacter pylori Screen\u2010And\u2010Treat Strategies for Gastric Cancer Prevention: Guidance on Implementation","author":"Park J. Y.","year":"2025"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.70071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T06:02:35Z","timestamp":1763272955000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hel.70071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/hel.70071"],"URL":"https:\/\/doi.org\/10.1111\/hel.70071","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-07-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70071"}}