{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:02:04Z","timestamp":1791061324439,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":52,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2025,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background and Aim<\/jats:title>\n \n While\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n infection is more commonly associated with adults, it can affect children with an impact on their well\u2010being. Vonoprazan is effective in the eradication of\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n infection in adults. However, its effectiveness in adolescents and children is still being studied. The study aimed to investigate the efficacy of Vonoprazan\u2010based triple therapy (VTT) compared to Esomeprazole\u2010based triple therapy (ETT) for\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n eradication in adolescents and children.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n In a multicenter, double\u2010blind, randomized controlled design, we included 242 participants with\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n infection in the age group 10\u201318\u2009years. They were randomly assigned to either weight\u2010based Esomeprazole\/Amoxicillin\/Clarithromycin twice daily for 14\u2009days (ETT) or to Vonoprazan 20\u2009mg\/weight\u2010based Amoxicillin\/Clarithromycin twice daily for 14\u2009days (VTT). The\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n eradication was evaluated 8\u2009weeks after therapy. Treatment\u2010related adverse events were reported.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In intention\u2010to\u2010treat analysis, eradication of\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n was achieved in 93 (76.9%) of the ETT arm and in 106 (87.6%) of the VTT arm (\n p<\/jats:italic>\n \u2009=\u20090.029). In per\u2010protocol analysis, eradication rates were 83% and 92.2% for ETT and VTT, respectively (\n p<\/jats:italic>\n \u2009=\u20090.036). There was no difference between the two study arms in terms of overall adverse events (\n p<\/jats:italic>\n \u2009=\u20090.46). In the VTT arm, the most frequent adverse events were diarrhea (5.8%) and nausea (6.6%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Fourteen days of VTT is superior to ETT for\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n eradication and is well tolerated in children and adolescents aged between 10 and 18\u2009years.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registry<\/jats:title>\n \n NCT06162949;\n https:\/\/clinicaltrials.gov\/study\/NCT06162949<\/jats:ext-link>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/hel.70083","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T04:55:26Z","timestamp":1761281726000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Vonoprazan\u2010Based Triple Therapy Versus Esomeprazole\u2010Based Triple Therapy for\n \n H. pylori<\/i>\n <\/scp>\n Eradication in Adolescents (\n VONTAPE<\/scp>\n ): A Randomized, Double\u2010Blind Controlled Trial"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8599-1338","authenticated-orcid":false,"given":"Sameh A.","family":"Lashen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine (Gastroenterology and Hepatology Division), Faculty of Medicine Alexandria University Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed M.","family":"Shamseyea","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Internal Medicine Medical Research Institute, Alexandria University Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha H.","family":"Metwally","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine, Alexandria University Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galal","family":"Abou\u2010Farrag","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Gastroenterology, and Infectious Diseases Faculty of Medicine, Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Engy S.","family":"Elkaragy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine, Alexandria University Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2012.00975.x"},{"issue":"8","key":"e_1_2_11_3_1","first-page":"72","article-title":"Helicobacter Pylori, Transmission Routes, and Recurrence of Infection: State of the Art","volume":"89","author":"Kayali S.","year":"2018","journal-title":"Acta Bio\u2010Medica"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00431-8"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(21)00400-4"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.21608\/aeji.2023.240219.1327"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/1319-3767.48964"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjpo-2020-000679","article-title":"Helicobacter Pylori Infection in Children","volume":"4","author":"Matos I. A.","year":"2020","journal-title":"BMJ Paediatrics Open"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(93)90235-9"},{"key":"e_1_2_11_10_1","first-page":"76","article-title":"Long\u2010Term Follow\u2010Up of Duodenal Ulcer in Children Before and After Eradication of Helicobacter Pylori","volume":"28","author":"Huang F. C.","year":"1999","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ256"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12400"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001594"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.09.007"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00485.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/87551225231166531"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.5897\/AJB2010.000-3015"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-022-01942-z"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11060757"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312288"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-020-01709-4"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpn3.12314"},{"issue":"4","key":"e_1_2_11_23_1","first-page":"1287","article-title":"Helicobacter Pylori Antibiotic Resistance Patterns Among Egyptian Children and Predictors of Resistance","volume":"4","author":"Abdallah N.","year":"2023","journal-title":"Microbes and Infectious Diseases"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S386082"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-023-02707-5"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.146.1MA7.591a"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-014-0450-6"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.2521-18"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12696"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-017-1406-2"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.4292\/wjgpt.v9.i7.63"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13325"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12059"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm18029"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i4.668"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.c21-00164"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.29.6.680"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13588"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-311304"},{"key":"e_1_2_11_40_1","article-title":"Vonoprazan as a Long\u2010Term Maintenance Treatment for Erosive Esophagitis: VISION, a 5\u2010Year, Randomized, Open\u2010Label Study","volume":"24","author":"Uemura N.","year":"2024","journal-title":"Clinical Gastroenterology and Hepatology"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.70083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T06:02:27Z","timestamp":1763272947000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hel.70083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/hel.70083"],"URL":"https:\/\/doi.org\/10.1111\/hel.70083","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2024-12-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70083"}}