{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:29:17Z","timestamp":1773188957448,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2025,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Current\n \n Helicobacter pylori<\/jats:styled-content>\n (\n H. pylori<\/jats:styled-content>\n )\n <\/jats:italic>\n eradication regimens\u2014standard triple, bismuth\u2010containing quadruple, and non\u2010bismuth quadruple therapies\u2014still face issues such as adverse effects and poor compliance. High\u2010dose dual therapy, with its simplicity, lower pill burden, and comparable efficacy, has recently gained attention. However, existing studies are largely single\u2010center with small sample sizes and lack sufficient evidence\u2010based support. This study aims to further evaluate the efficacy and safety of ilaprazole\u2010based dual and quadruple therapies for\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n eradication.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This was a prospective, multicenter, randomized controlled, non\u2010inferiority clinical trial conducted at five hospitals from January to November 2023. A total of 480 patients were randomly assigned to one of three treatment groups for 14\u2009days: Group A (ilaprazole 5\u2009mg, amoxicillin 1\u2009g, clarithromycin 500\u2009mg, and bismuth potassium citrate 220\u2009mg, all administered twice daily), Group B (ilaprazole 5\u2009mg twice daily and amoxicillin 1\u2009g three times daily), and Group C (ilaprazole 10\u2009mg twice daily and amoxicillin 1\u2009g three times daily). The eradication rates, adverse events, and patient compliance were recorded.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The eradication rates of\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n in Groups A, B, and C were 76.9%, 88.1%, and 88.7% (\n p<\/jats:italic>\n \u2009=\u20090.004) by intention\u2010to\u2010treat analysis, respectively, and 78.3%, 90.4%, and 91.0% (\n p<\/jats:italic>\n \u2009=\u20090.001) using modified intention\u2010to\u2010treat analysis, and 81.8%, 92.1%, 92.2% (\n p<\/jats:italic>\n \u2009=\u20090.005) by per\u2010protocol analysis. The adverse event rates were 28.0%, 10.2%, 10.8% in Groups A, B, and C, respectively (\n p\u2009<<\/jats:italic>\n \u20090.001), while patient compliance rates were 91.1%, 98.1%, 98.7%, respectively (\n p\u2009=<\/jats:italic>\n \u20090.001). Sex, smoking history, alcohol intake, and sharing tableware or cups did not affect the efficacy of the three treatment regimens.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The standard\u2010 or high\u2010dose dual therapy with ilaprazole demonstrated superior efficacy, safety, and patient compliance compared to quadruple therapy. No significant differences were observed between these dual therapies, which are expected to become promising alternatives for the primary treatment of\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n infection.\n <\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n Chinese Clinical Trial Registry: ChiCTR2400086862<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/hel.70086","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T11:32:21Z","timestamp":1762774341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Different Doses of Ilaprazole for Dual Therapy Versus Bismuth\u2010Quadruple Therapy for\n \n Helicobacter pylori<\/i>\n <\/scp>\n Infection: A Three\u2010Arm, Randomized Clinical Trial"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8056-1031","authenticated-orcid":false,"given":"Qiang","family":"Han","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The First Hospital of Tsinghua University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Zu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyu","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology China\u2010Japan Friendship Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinyan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Beijing Haidian Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanmin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Aerospace Center Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yali","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Hospital of Tsinghua University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuqing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Hospital of Tsinghua University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Hospital of Tsinghua University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanli","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Hospital of Tsinghua University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0831-0965","authenticated-orcid":false,"given":"Shigang","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12403"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751\u20102980.12034"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15751"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens11070786"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002546"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.8598.1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16158"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.771876"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197\u20102456(00)00088\u2010X"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12014"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102016\u2010312288"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12046"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i9.2786"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz046"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10194352"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100043"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12860"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2899"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12475"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876\u2010023\u201002890\u20105"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1272744"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.5582\/ddt.2020.01011"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12804"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1648047"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.70086","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hel.70086","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.70086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T07:32:33Z","timestamp":1771140753000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hel.70086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/hel.70086"],"URL":"https:\/\/doi.org\/10.1111\/hel.70086","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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