{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:17:09Z","timestamp":1789391829307,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2025,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n \n Helicobacter pylori<\/jats:italic>\n <\/jats:styled-content>\n (\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n ) infection is a significant risk factor for gastric cancer. The effective implementation of strategies to mitigate gastric cancer requires widespread dissemination of information regarding\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n , diagnostic methods, and preventive measures. Despite the high incidence of gastric cancer, efforts to disseminate this information are lacking in Japan. Therefore, our survey aimed to evaluate\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n and gastric cancer awareness in Japan and identify factors associated with\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n knowledge, focusing on health literacy.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n This nationwide cross\u2010sectional survey was conducted online. We developed a questionnaire on\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n awareness and knowledge across four domains: infection risk,\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n \u2010related diseases, testing and treatment, and gastric cancer\u2010related problems. In addition, we evaluated health literacy using an established health literacy scale. Multivariable regression analysis was conducted using the\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n knowledge score as the dependent variable.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Over half of the 3095 respondents were aware of\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n infection (56.4%). The overall correct response rate for the\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n knowledge questions was 45.7%, with varying performances across the knowledge domains: infection risk (57.3%),\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n \u2010related diseases (50.9%), testing and treatment (37.5%), and gastric cancer (44.4%). The regression models identified the following factors as associated with a higher\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n knowledge: older age, higher health literacy scores, previous\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n testing, and healthcare professional status. Among participants without prior\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n testing, higher\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n knowledge scores were associated with a greater willingness to undergo\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n screening.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n To our knowledge, this is the first nationwide assessment of\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n infection and gastric cancer awareness in Japan. Health literacy and previous\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n screening were significantly associated with\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n knowledge. The development of educational strategies for these factors may be desirable for gastric cancer prevention.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/hel.70089","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T04:04:51Z","timestamp":1762920291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Survey on Awareness of\n \n Helicobacter pylori<\/i>\n <\/scp>\n and Gastric Cancer in the Japanese Population Using an Internet Survey"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2337-7417","authenticated-orcid":false,"given":"Chihiro","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Department of Radiation Health Management Fukushima Medical University School of Medicine Fukushima Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0824-454X","authenticated-orcid":false,"given":"Hiroaki","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Radiation Health Management Fukushima Medical University School of Medicine Fukushima Fukushima Japan"},{"name":"Department of Internal Medicine Soma Central Hospital Soma Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Health Informatics Kyoto University School of Public Health Sakyo\u2010ku Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5971-2256","authenticated-orcid":false,"given":"Yoshika","family":"Saito","sequence":"additional","affiliation":[{"name":"Sendai Kousei Hospital Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiga","family":"Uchiyama","sequence":"additional","affiliation":[{"name":"Department of Radiation Health Management Fukushima Medical University School of Medicine Fukushima Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9995-5522","authenticated-orcid":false,"given":"Toshihiko","family":"Kakiuchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Saga University Saga Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4693-5736","authenticated-orcid":false,"given":"Yuichiro","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Loco Medical General Institute Ogi Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Ma\u2010Ru Clinic Yokosuka Yokosuka Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Tsubokura","sequence":"additional","affiliation":[{"name":"Department of Radiation Health Management Fukushima Medical University School of Medicine Fukushima Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2007.02.002"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr384"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28999"},{"key":"e_1_2_10_5_1","unstructured":"World Cancer Research Fund \u201cStomach Cancer Statistics \u201d accessed January 17 2025 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