{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T18:59:43Z","timestamp":1781204383637,"version":"3.54.1"},"reference-count":63,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Previous studies have established an association between\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Helicobacter pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      (\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      ) infection and metabolic dysfunction\u2010associated steatotic liver disease (MASLD). However, the specific effects of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      eradication therapy on MASLD patients remain unclear. Therefore, this systematic review and meta\u2010analysis aims to comprehensively evaluate the impact of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      eradication therapy on the incidence and clinical course of MASLD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Cohort studies and randomized controlled trials (RCTs) were systematically retrieved from PubMed, Embase, Cochrane Library, and Web of Science. Hazard ratios (HRs) from cohort studies and mean differences (MDs) from RCTs with their corresponding 95% confidence intervals (CIs) were calculated to assess the impact of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      eradication therapy on MASLD risk and changes in laboratory parameters. Subgroup analyses were performed based on varying follow\u2010up periods and intervention type. Sensitivity analyses were conducted to assess the robustness of the findings. Funnel plots were used to evaluate publication bias.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eight studies, including two cohort studies assessing the incidence risk and six RCTs analyzing laboratory parameters, were included, encompassing a total of 5320 participants. All eligible studies were subjected to meta\u2010analysis of their respective outcomes.\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      eradication therapy was found to significantly lower the risk of developing MASLD (HR\u2009=\u20090.74, 95% CI: 0.65\u20130.85). In patients already diagnosed with MASLD, eradication therapy was associated with reductions in waist circumference (MD\u2009=\u2009\u22120.62, 95% CI: \u22121.20 to \u22120.03), aspartate aminotransferase (AST; MD\u2009=\u2009\u22122.12, 95% CI: \u22122.78 to \u22121.45), fasting blood glucose (FBG; MD\u2009=\u2009\u22120.33, 95% CI: \u22120.66 to \u22120.01), homeostasis model assessment of insulin resistance (HOMA\u2010IR; MD\u2009=\u2009\u22120.21, 95% CI: \u22120.25 to \u22120.17).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The application of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      eradication therapy correlates with a reduced risk of MASLD and favorable changes in anthropometric, hepatic, glycemic, and inflammatory outcomes, though these benefits may vary depending on the duration of follow\u2010up and eradication methods.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.70092","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T05:10:25Z","timestamp":1764565825000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of\n                    <i>Helicobacter pylori<\/i>\n                    Eradication on the Risk and Clinical Parameters of Metabolic Dysfunction\u2010Associated Steatotic Liver Disease: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1433-3486","authenticated-orcid":false,"given":"Xiang","family":"Li","sequence":"first","affiliation":[{"name":"Center of Stomatology, The Second Affiliated Hospital Jiangxi 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