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Determining eradication rates of different treatment regimens can inform antibiotic resistance. Our aim was to examine eradication rates of empiric\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      treatments based on treatment regimen, race\/ethnicity and previous treatment status in a multiethnic U.S. population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      This was a retrospective cross\u2010sectional study of patients with a positive\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      test from 7\/2021 to 4\/2022 at Harris Health (Houston, Texas) who had received treatment and eradication testing within 1\u2009year. We compared eradication rates based on treatment regimen, race\/ethnicity, and prior treatment and examined other possible risk factors for treatment failure using logistic regression models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1106\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      \u2010infected patients, 29.2% were male, 80.6% Hispanic, 10.7% black, 2.5% white, and 83.3% were non\u2010U.S. born with a mean age of 50.8\u2009years (standard deviation 12.6). Most patients (57.3%) received bismuth\u2010tetracycline\u2010metronidazole quadruple, 21.2% clarithromycin\u2010metronidazole\u2010amoxicillin quadruple, 15.6% clarithromycin\u2010amoxicillin triple, and 3.9% received clarithromycin\u2010metronidazole triple therapies. Eradication rates were highest for bismuth\u2010tetracycline\u2010metronidazole quadruple (83.8%), clarithromycin\u2010metronidazole\u2010amoxicillin quadruple (80.3%), and clarithromycin\u2010amoxicillin triple therapies (79.2%). In 186 (16.8%) previously treated patients, all empiric regimens achieved &lt;\u200980% eradication rates. Clarithromycin\u2010amoxicillin triple had high eradication rates (92.9%) in black patients and bismuth quadruple therapy in Asians (95.8%). Compared to bismuth quadruple therapy, clarithromycin\u2010metronidazole triple (adjusted odds ratio [adjOR] 0.31, 95% confidence interval [CI] 0.13\u20130.73) and levofloxacin\u2010amoxicillin triple (adjOR 0.20, 95% CI 0.05\u20130.89) regimens were associated with treatment failure, whereas clarithromycin\u2010amoxicillin quadruple and triple therapies were not.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Empiric bismuth quadruple therapy had the highest eradication rate while metronidazole and levofloxacin triple therapies had the lowest. Eradication rates may thus serve as a surrogate clinical endpoint when choosing empiric therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.70095","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T06:05:37Z","timestamp":1765260337000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Eradication Rates of Empiric\n                    <scp>\n                      <i>Helicobacter pylori<\/i>\n                    <\/scp>\n                    Treatment Regimens by Race\/Ethnicity in a Predominantly Immigrant U.S. Population"],"prefix":"10.1111","volume":"30","author":[{"given":"Min J.","family":"Kim","sequence":"first","affiliation":[{"name":"Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isiah","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Medicine Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nia M.","family":"Choi","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David Y.","family":"Graham","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology and Hepatology, Department of Medicine Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hashem B.","family":"El\u2010Serag","sequence":"additional","affiliation":[{"name":"Department of Medicine Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6113-4780","authenticated-orcid":false,"given":"Mimi C.","family":"Tan","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology and Hepatology, Department of Medicine Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.04.022"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.05.016"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/usac428"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.03.059"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastha.2022.06.001"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.563"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28999"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.2.468-470.1997"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/166.1.149"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07273-2"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.9"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92035-Z"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000519413"},{"key":"e_1_2_9_15_1","first-page":"313","article-title":"Helicobacter pylori\n                   Treatment Regimens: A US Perspective","volume":"18","author":"Ho J. 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