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The objectives of the EUROHELICAN project were to assess the feasibility, acceptability, effectiveness, and adverse events of the\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      screen\u2010and\u2010treat program in younger adults aged 30 to 34\u2009years, for the first time in Europe; to evaluate long\u2010term effects of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      eradication in middle\u2010aged adults (starting from 45\u2009years of age) previously enrolled for at least 5\u2009years in the GISTAR study in Latvia, and to prepare the IARC expert Working Group Report on population\u2010based\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      screen\u2010and\u2010treat strategies for gastric cancer prevention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The study of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      screen\u2010and\u2010treat in younger adults was conducted in the Community Healthcare Center Dr. Adolf Drolc Maribor following methodology prepared by the National Institute of Public Health of Slovenia. Assessment of possible effects of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      screen\u2010and\u2010treat in the long term was conducted by following up on the long\u2010running GISTAR study conducted by the Institute of Clinical and Preventive Medicine at the University of Latvia. A team of experts led by the Nantes University Hospital evaluated the study protocols and their progress at different stages. The IARC convened a Working Group of international experts to develop globally applicable guidance on best practices for implementing population\u2010based\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      screen\u2010and\u2010treat strategies in adult populations to prevent gastric cancer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Both studies received a positive evaluation at different stages of completion and were deemed appropriate for testing the feasibility of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      screen\u2010and\u2010treat in a community health care setting and investigating possible adverse effects of the strategy in the long\u2010term. The IARC expert group guidance report on the implementation of population\u2010based\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      screen\u2010and\u2010treat strategies to prevent gastric cancer in adults will guide future primary gastric cancer prevention programs in Europe and beyond.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.70097","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T10:00:53Z","timestamp":1767780053000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>EUROHELICAN<\/scp>\n                    \u2014Accelerating Gastric Cancer Reduction Through\n                    <scp>\n                      <i>Helicobacter pylori<\/i>\n                    <\/scp>\n                    Eradication"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5616-4333","authenticated-orcid":false,"given":"Bojan","family":"Tepe\u0161","sequence":"first","affiliation":[{"name":"National Institute of Public Health  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1552-4278","authenticated-orcid":false,"given":"Tatjana Kofol","family":"Bric","sequence":"additional","affiliation":[{"name":"National Institute of Public Health  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0057-6013","authenticated-orcid":false,"given":"Mitja","family":"Oblak","sequence":"additional","affiliation":[{"name":"National Institute of Public Health  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5023-0483","authenticated-orcid":false,"given":"Jernej","family":"Zavr\u0161nik","sequence":"additional","affiliation":[{"name":"Community Healthcare Center Dr. Adolf Drolc  Maribor Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1998-7346","authenticated-orcid":false,"given":"Helena Bla\u017eun","family":"Vo\u0161ner","sequence":"additional","affiliation":[{"name":"Community Healthcare Center Dr. Adolf Drolc  Maribor Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3069-0140","authenticated-orcid":false,"given":"Danute","family":"Ra\u017euka\u2010Ebela","sequence":"additional","affiliation":[{"name":"University of Latvia, Institute of Clinical and Preventive Medicine  Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0319-8855","authenticated-orcid":false,"given":"M\u0101rcis","family":"Leja","sequence":"additional","affiliation":[{"name":"University of Latvia, Institute of Clinical and Preventive Medicine  Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9646-2052","authenticated-orcid":false,"given":"Viktoria","family":"Knaze","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer (IARC)  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2491-5099","authenticated-orcid":false,"given":"Jin Young","family":"Park","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer (IARC)  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0780-6261","authenticated-orcid":false,"given":"Tamara","family":"Matysiak\u2010Budnik","sequence":"additional","affiliation":[{"name":"IMAD &amp; 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