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This report reviews the development of the population\u2010based\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H.\u2009pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    screen\u2010and\u2010treat strategy as a healthcare policy for gastric cancer prevention in Taiwan from 2004 to 2025, tracing its evolution from localized pilot programs to regional initiatives and, ultimately, to full population\u2010wide implementation. To support systematic implementation at the population level, Taiwan adopted a three\u2010tiered foundation that includes: (1) a centralized planning committee; (2) screening service delivery through primary care providers, guided by clinical guidelines established by medical societies; and (3) community engagement to raise awareness of stomach health and promote participation in screen\u2010and\u2010treat programs through social media campaigns. Program execution strictly follows the principles of organized screening, supported by standardized quality indicators, integrated digital tracking systems, structured audit mechanisms, and both effectiveness and cost\u2010effectiveness assessments. Strategies are tailored to local contexts: in the Matsu Islands, mass screening using the\n                    <jats:sup>13<\/jats:sup>\n                    C urea breath test and subsequent eradication treatment led to reductions in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H.\u2009pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    prevalence and gastric cancer incidence and mortality; in Changhua County, a pragmatic randomized clinical trial showed that stool sample\u2010based screening using\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H.\u2009pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    stool antigen and fecal immunochemical testing improved participation and reduced gastric cancer incidence; and in indigenous communities, household\u2010based approaches utilizing the\n                    <jats:sup>13<\/jats:sup>\n                    C urea breath test could enhance\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H.\u2009pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    detection rate and reduce the intrafamilial transmission. In addition to the continuous assessment of its effectiveness in preventing both gastric cancer and peptic ulcer disease, it is also essential to evaluate the potential impacts on antibiotic resistance and gut microbial succession after mass\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H.\u2009pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    eradication. All these programs consistently maintain high standards of quality and equity, ensuring accessibility for diverse populations with varying socioeconomic positions. Collectively, it demonstrates how robust scientific evaluations, when combined with organized screening principles and systematic performance monitoring, can be effectively translated into sustainable, evidence\u2010based programs for population\u2010wide gastric cancer prevention.\n                  <\/jats:p>","DOI":"10.1111\/hel.70102","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T04:36:09Z","timestamp":1769661369000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Gastric Cancer Prevention in Taiwan: Past Achievements and Future Perspectives"],"prefix":"10.1111","volume":"31","author":[{"given":"Shu\u2010Lin","family":"Chuang","sequence":"first","affiliation":[{"name":"Department of Medical Research National Taiwan University Hospital  Taipei City 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Taiwan"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine National Taiwan University  Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-023-00747-0"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2025-336027"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00070-5"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-320234"},{"key":"e_1_2_15_8_1","unstructured":"Ministry of Health and Welfare \u201cThe Leading Causes of Death in Taiwan 2024 \u201dTaiwan: Ministry of Health and Welfare; (2025) accessed on December 11 2025 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