{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:09:39Z","timestamp":1778695779914,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004329","name":"The Slovenian Research and Innovation Agency","doi-asserted-by":"publisher","award":["P3\u20100154"],"award-info":[{"award-number":["P3\u20100154"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n To achieve eradication rates >\u200990%, the ESPGHAN\/NASPGHAN guidelines for pediatric\n \n Helicobacter pylori<\/jats:italic>\n <\/jats:styled-content>\n infection recommend tailored antimicrobial therapy using sufficiently high doses over 10\u201314\u2009days. However, prolonged treatment often leads to suboptimal compliance in children, which is a major contributor to reduced eradication rates. To address this, we evaluated the efficacy and safety of a shorter, 7\u2009day triple therapy with bismuth compared with the 14\u2009day standard triple therapy without bismuth in\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n infected children.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n From 2020 to 2024, we carried out a randomized controlled trial involving treatment\u2010na\u00efve children and adolescents (5\u201318\u2009years old) with confirmed\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n infection. Eligible participants were randomly allocated to receive either a 7\u2009day triple therapy with bismuth (bismuth subcitrate, a proton pump inhibitor [PPI], amoxicillin, plus clarithromycin\/metronidazole) or a 14\u2009day standard triple therapy (a PPI, amoxicillin, plus clarithromycin\/metronidazole) without bismuth. Two months after completing therapy, treatment success was determined using either a two\u2010step monoclonal stool antigen assay or a urea breath test. Any adverse events were documented using a structured questionnaire.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Seventy\u2010three children were enrolled in the study. In the intention\u2010to\u2010treat analysis, eradication was achieved in 91% of children treated with the 7\u2009day triple therapy with bismuth and 87% of those receiving the 14\u2009day standard triple therapy (\n p<\/jats:italic>\n \u2009=\u20090.695). Per\u2010protocol eradication rates were 94% and 87%, respectively (\n p<\/jats:italic>\n \u2009=\u20090.418). No serious adverse events were reported, and most adverse events were mild to moderate. A metallic taste was significantly more frequent in the 14\u2009day standard triple therapy group, while other adverse events occurred with similar frequency.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Adding bismuth to a 7\u2009day triple regimen achieved high eradication rates and a safety profile similar to 14\u2009day standard triple therapy, supporting its use as an effective and safe treatment option for pediatric\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n infection.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/hel.70103","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T11:36:44Z","timestamp":1767785804000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An Open\u2010Label Randomized Controlled Trial Comparing the Efficacy and Safety of a 7\u2010Day Triple Therapy With Bismuth Versus 14\u2010Day Standard Triple Therapy for\n \n Helicobacter pylori<\/i>\n <\/scp>\n Eradication in Children and Adolescents"],"prefix":"10.1111","volume":"31","author":[{"given":"Anja","family":"\u0160terbenc","sequence":"first","affiliation":[{"name":"Institute of Microbiology and Immunology, Faculty of Medicine University of Ljubljana Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bor","family":"Vratanar","sequence":"additional","affiliation":[{"name":"Institute for Biostatistics and Medical Informatics, Faculty of Medicine University of Ljubljana Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva Miler","family":"Moj\u0161kerc","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Slovenj Gradec General Hospital Slovenj Gradec Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5764-5430","authenticated-orcid":false,"given":"Matja\u017e","family":"Homan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Nutrition, University Children's Hospital, Faculty of Medicine University of Ljubljana Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00070-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.12.022"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9080436"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12679"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12825"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpn3.12314"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12383"},{"issue":"1","key":"e_1_2_10_9_1","first-page":"10","article-title":"Advances in the Treatment of \n Helicobacter pylori\n Infection in Children","volume":"28","author":"Kalach N.","year":"2015","journal-title":"Annals of 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