{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:22:09Z","timestamp":1791926529182,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"vor","delay-in-days":49,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Gastric cancer (GC) is the fifth leading cause of cancer\u2010related mortality globally; its main burden is concentrated in East Asia and some areas of Europe and Latin America. This study aims to develop an organized and structured GC prevention pilot program in intermediate\u2010to\u2010high\u2010incidence countries in Latin America.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study involved two strategies: (a) primary prevention for\n                      <jats:italic>\n                        screen\u2010and\u2010treat\n                        <jats:styled-content style=\"fixed-case\">H. pylori<\/jats:styled-content>\n                      <\/jats:italic>\n                      infection among individuals aged 30\u201339\u2009years (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097500, 500 in 15 sites), and (b) primary and secondary prevention for individuals aged 40\u201375\u2009years (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099600, 600 in 16 sites) with tiered risk stratification using an algorithm developed and validated in Chile (Gastrocalc: priority 1 to 6; age, sex, hypertension, IgG\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      , pepsinogen I and II, and Gastrin\u201017b), and high\u2010quality esophagogastroduodenoscopy (EGD) evaluation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Pilot phases were successfully conducted in Chile and Colombia during 2023\u20132025. In Chile (Molina), 4152 asymptomatic individuals were tested with\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      prevalence of 46% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009113\/246) in 2023, 34% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009504\/1484) in 2024, and 32% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009609\/1904) in 2025. The\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      prevalence among individuals aged 30\u201339\u2009years (592\/4152; 14.3%) was 37.8%. In Colombia, 1250 asymptomatic individuals were screened across four regions; in 2025, the prevalence of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      among individuals aged 30\u201339\u2009years was 69% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009895\/1250). The validation of Gastrocalc included 866 individuals from 5 regions in Chile. The algorithm successfully identified 80.6% of OLGA III\u2013IV patients and 100% of GC patients (Priority 1\u20134). Other countries will start activities in 2026.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This pioneering study will advance understanding and feasibility of urgently needed primary and secondary prevention for GC in Latin America.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.70109","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T02:59:23Z","timestamp":1776653963000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hope\n                    <scp>Hp\u2010GC<\/scp>\n                    Project\u2014Program Implementation for Primary and Secondary Prevention of Gastric Cancer in Latin 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