{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:43:31Z","timestamp":1792496611196,"version":"4.5.0"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Vonoprazan (VPZ), a potassium\u2010competitive acid blocker, has shown promising efficacy in\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Helicobacter pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      (\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      ) eradication. However, direct comparisons of VPZ\u2010based dual therapy (V\u2010DT), triple therapy (V\u2010TT), and bismuth quadruple therapy (V\u2010BQT) remain limited. This study aimed to evaluate and compare the efficacy, safety, and compliance of these three regimens as first\u2010line treatments for\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      375 adults were randomized (1:1:1) to receive V\u2010DT (VPZ 20\u2009mg bid + amoxicillin 1\u2009g tid for 10\u2009days), V\u2010TT (VPZ 20\u2009mg bid + amoxicillin 1\u2009g bid + clarithromycin 500\u2009mg bid for 14\u2009days), or V\u2010BQT (VPZ 20\u2009mg bid + amoxicillin 1\u2009g bid + clarithromycin 500\u2009mg bid + bismuth 240\u2009mg bid for 10\u2009days). The primary outcome was\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      eradication rate by intention\u2010to\u2010treat (ITT), modified ITT (mITT), and per\u2010protocol (PP) analyses. Secondary outcomes included adverse events and compliance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eradication rates were 92.0% (95% confidence interval [CI]: 85.8%\u201396.1%), 89.6% (95% CI: 82.9%\u201394.3%), and 88.8% (95% CI: 81.9%\u201393.7%) in ITT; 94.3% (95% CI: 88.5%\u201397.7%), 94.9% (95% CI: 89.3%\u201398.1%), and 94.1% (95% CI: 88.2%\u201397.6%) in mITT; and 94.2% (95% CI: 88.4%\u201397.6%), 95.6% (95% CI: 90.0%\u201398.5%), and 94.8% (95% CI: 89.0%\u201398.1%) in PP analyses for V\u2010DT, V\u2010TT, and V\u2010BQT, respectively. The efficacy of V\u2010DT and V\u2010TT was noninferior to that of V\u2010BQT. Adverse events were significantly lower with V\u2010DT (6.4%) than with V\u2010TT (36.0%) and V\u2010BQT (49.6%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Compliance exceeded 93% in all groups, with no significant differences (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.250).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      All three regimens achieved high eradication rates, with V\u2010DT and V\u2010TT being statistically noninferior to V\u2010BQT. The 10\u2010day\u2009V\u2010DT regimen achieved eradication rates comparable to V\u2010BQT with substantially fewer adverse events and reduced antibiotic use, supporting its potential as a simplified first\u2010line option for\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      eradication.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Chinese Clinical Trial Registration Number: ChiCTR2300072857<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.70112","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:51:36Z","timestamp":1773028296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and Safety of Vonoprazan\u2010Based Dual, Triple, and Quadruple Therapies for\n                    <scp>\n                      <i>Helicobacter pylori<\/i>\n                    <\/scp>\n                    Eradication: A Randomized Controlled Trial"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0267-5397","authenticated-orcid":false,"given":"Jin\u2010Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University  Xiamen China"},{"name":"The Graduate School of Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Feng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University  Xiamen China"},{"name":"The Graduate School of Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Yi","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University  Xiamen China"},{"name":"The Graduate School of Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Lin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui\u2010Hua","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.12.022"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00431-8"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327745"},{"key":"e_1_2_12_5_1","first-page":"1","article-title":"Schistosomes, Liver Flukes and \n                     Helicobacter pylori","volume":"61","year":"1994","journal-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.03.039"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11050593"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.13708"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03153-w"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-326583"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.13013"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i14.2202"},{"issue":"3","key":"e_1_2_12_13_1","first-page":"159","article-title":"Best Practices for \n                     Helicobacter pylori\n                   Management","volume":"20","author":"Graham D. Y.","year":"2024","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2023.05.014"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2024.107325"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12475"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2025-335523"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-89073-2"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.15611"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.563"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.04.006"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v30.i9.1213"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.13148"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.13637"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002546"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002592"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v31.i1.101463"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562848241309870"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-311304"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17070"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002086"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15917"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.04.012"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-020-01723-6"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15837"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b24-00011"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.13166"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-024-09885-x"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-024-08460-3"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12495"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i16.1907"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph13100276"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.111.179556"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm18139"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000132"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2010.08.007"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1053\/bega.2001.0188"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(17)30219-4"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw118"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.13133"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12896"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.05.055"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1324"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2016.01.009"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60743-1"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.27.8.1081"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2019.10.008"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.70112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hel.70112","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.70112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:25:28Z","timestamp":1792495528000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hel.70112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/hel.70112"],"URL":"https:\/\/doi.org\/10.1111\/hel.70112","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70112"}}