{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:43:18Z","timestamp":1792496598369,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate the associations of both baseline serological profiles and serological transitions of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Helicobacter pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection patterns with the risk of precancerous gastric lesions (PGLs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>\n                      We analyzed data from 6208 participants in the\n                      <jats:styled-content style=\"fixed-case\">FuSion<\/jats:styled-content>\n                      cohort who underwent gastroscopy examination, with available\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      antibody and pepsinogen measurements at both baseline and follow\u2010up.\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      status defined by\n                      <jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content>\n                      antibodies (Ab) and pepsinogens (\n                      <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>\n                      ), classified participants into four\n                      <jats:styled-content style=\"fixed-case\">ABC<\/jats:styled-content>\n                      groups. Multivariable logistic regression evaluated associations with\n                      <jats:styled-content style=\"fixed-case\">PGLs<\/jats:styled-content>\n                      across baseline and transition statuses. Trend tests were performed across the\n                      <jats:styled-content style=\"fixed-case\">ABC<\/jats:styled-content>\n                      groups and infection transition categories.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A significant increasing trend in the PGLs prevalence and severity was observed across the ABC groups (\n                      <jats:italic>p<\/jats:italic>\n                      for trend &lt;\u20090.05). Analysis of infection transitions revealed graded risk increases for PGLs from consistently negative to remained positive groups. Interestingly, even participants who seroreverted remained at significantly elevated risks of atrophic gastritis (adjusted odds ratio [aOR]\u2009=\u20092.01, 95% CI: 1.67\u20132.43) and intestinal metaplasia (aOR\u2009=\u20091.72, 95% CI: 1.14\u20132.51) compared to the persistently negative participants. The sensitivity analyses excluding baseline PG\u2010positive subjects yielded similar results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Long\u2010term exposure to\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      is associated with an increased risk of PGLs, and this risk may remain elevated even after seroreversion.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.70114","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:59:06Z","timestamp":1773010746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Changes of\n                    <i>Helicobacter pylori<\/i>\n                    Infection Status and Risk of Precancerous Lesions: A Prospective Cohort Study in Chinese Population"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0581-7794","authenticated-orcid":false,"given":"Xufei","family":"Xing","sequence":"first","affiliation":[{"name":"Shanghai Institute of Infectious Disease and Biosecurity Fudan University  Shanghai China"},{"name":"Department of Epidemiology, Ministry of Education Key Laboratory of Public Health Safety, School of Public Health Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renjia","family":"Zhao","sequence":"additional","affiliation":[{"name":"Fudan University Taizhou Institute of Health Sciences  Taizhou China"},{"name":"State Key Laboratory of Genetics and Development of Complex Phenotypes, Human Phenome Institute, Zhangjiang Fudan International Innovation Center Fudan University  Shanghai 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Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6788-4256","authenticated-orcid":false,"given":"Kelin","family":"Xu","sequence":"additional","affiliation":[{"name":"Fudan University Taizhou Institute of Health Sciences  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5187-7393","authenticated-orcid":false,"given":"Tiejun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Ministry of Education Key Laboratory of Public Health Safety, School of Public Health Fudan University  Shanghai China"},{"name":"Fudan University Taizhou Institute of Health Sciences  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5244-6894","authenticated-orcid":false,"given":"Zhenqiu","family":"Liu","sequence":"additional","affiliation":[{"name":"Fudan University Taizhou Institute of Health 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