{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:43:31Z","timestamp":1792496611254,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":31,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100031734","name":"Asociaci\u00f3n Espa\u00f1ola de Gastroenterolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031734","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015755","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015755","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","award":["10058099"],"award-info":[{"award-number":["10058099"]}],"id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Saccharomyces boulardii<\/jats:italic>\n CNCM I\u2010745 (Sb) is one of the most widely used probiotics in clinical practice. The aim of this study was to assess the impact of adding Sb to\n \n Helicobacter pylori<\/jats:italic>\n <\/jats:styled-content>\n eradication therapy on treatment outcomes (effectiveness and safety) in routine European gastroenterology clinical practice.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n Treatment\u2010naive cases from the European registry on\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n management (Hp\u2010EuReg) collected from 2013 to 2023 at AEG\u2010REDCap were analyzed. Effectiveness was assessed by modified intention\u2010to\u2010treat, by treatment and geographic regions. Multivariate analysis identified factors independently associated with eradication success and adverse event incidence.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 69,922 cases, probiotics were used in 16,528 (24%) treatments, of which 4404 (27%) included Sb. Sb use was significantly associated with an increase in effectiveness (OR\u2009=\u20092.32; 95% confidence interval, 1.38\u20134.03;\n p<\/jats:italic>\n \u2009<\u20090.01) only when prescribed with concomitant therapy encompassing a proton pump inhibitor plus clarithromycin\u2010amoxicillin\u2010metronidazole. In addition, a significant reduction in the overall incidence of at least one adverse event was observed in the Sb group (OR\u2009=\u20090.803; 0.66\u20130.97;\n p<\/jats:italic>\n \u2009<\u20090.05). Specifically, diarrhea, nausea, dyspepsia, abdominal pain, asthenia, anorexia, heartburn, and dysgeusia occurred significantly less frequently with Sb. Treatment compliance was high in both groups (with and without Sb).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In Europe, the addition of Sb to first\u2010line regimens in clinical practice was associated with higher effectiveness when combined with concomitant therapy with clarithromycin\u2010amoxicillin\u2010metronidazole and with fewer overall adverse events, supporting its role as a beneficial adjunct in\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n eradication therapy.\n <\/jats:p>\n <\/jats:sec>\n \n Registration Number<\/jats:title>\n \n ClinicalTrials.gov<\/jats:ext-link>\n identifier: NCT02328131\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/hel.70119","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T04:14:29Z","timestamp":1775103269000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Real\u2010World Effectiveness and Safety of\n Saccharomyces boulardii<\/i>\n CNCM<\/scp>\n I\u2010745 as Adjunct Therapy for\n \n Helicobacter pylori<\/i>\n <\/scp>\n Eradication: Data From the European Registry on\n \n H. pylori<\/i>\n <\/scp>\n Management (Hp\u2010\n EuReg<\/scp>\n )"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4920-9310","authenticated-orcid":false,"given":"Olga P.","family":"Nyssen","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS\u2010Princesa), Universidad Aut\u00f3noma de Madrid (UAM), and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9086-3675","authenticated-orcid":false,"given":"Laimas","family":"Jonaitis","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Lithuanian University of Health Sciences Kaunas Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2974-1382","authenticated-orcid":false,"given":"\u00c1ngeles","family":"P\u00e9rez\u2010A\u00edsa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital Universitario Costa del Sol, RICAPPS \u2010 Red de Investigaci\u00f3n en Cronicidad, Atenci\u00f3n Primaria y Prevenci\u00f3n y Promoci\u00f3n de la Salud Marbella Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5616-4333","authenticated-orcid":false,"given":"Bojan","family":"Tepes","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology DC Rogaska Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8932-8928","authenticated-orcid":false,"given":"Umud","family":"Mahmudov","sequence":"additional","affiliation":[{"name":"Memorial Hospital Baku Azerbaijan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Voynovan","sequence":"additional","affiliation":[{"name":"A.S. Loginov Moscow Clinical Scientific Center Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0857-8117","authenticated-orcid":false,"given":"Samuel J.","family":"Mart\u00ednez\u2010Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Cl\u00ednico Universitario Lozano Blesa, Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n (IIS Arag\u00f3n), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) Zaragoza Aragon Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Bujanda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Biodonostia Health Research Institute, Department of Medicine, Universidad del Pa\u00eds Vasco (UPV\/EHU), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo J.","family":"Lucendo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital General de Tomelloso, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS\u2010Princesa), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Investigaci\u00f3n Sanitaria de Castilla\u2010La Mancha (IDISCAM) Tomelloso Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila","family":"Vologzanina","sequence":"additional","affiliation":[{"name":"Gastrocentr Perm Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7960-3515","authenticated-orcid":false,"given":"Ana","family":"Garre","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS\u2010Princesa), Universidad Aut\u00f3noma de Madrid (UAM), and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frode","family":"Lerang","sequence":"additional","affiliation":[{"name":"\u00d8stfold Hospital Trust Gr\u00e5lum Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayar R.","family":"Abdulkhakov","sequence":"additional","affiliation":[{"name":"Kazan (Volga Region) Federal University, Kazan State Medical University Kazan Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Pavoni","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Sant'orsola\u2010Malpighi University Hospital Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6358-7282","authenticated-orcid":false,"given":"Maja","family":"Denkovski","sequence":"additional","affiliation":[{"name":"Interni Oddelek, Diagnostic Centre Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4629-350X","authenticated-orcid":false,"given":"Emin","family":"Mammadov","sequence":"additional","affiliation":[{"name":"Department of Therapy Azerbaijan State Advanced Training Institute for Doctors named after A. Aliyev, and Memorial Hospital Baku Azerbaijan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0319-8855","authenticated-orcid":false,"given":"M\u0101rcis","family":"Leja","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Digestive Diseases Centre, Institute of Clinical and Preventive Medicine, University of Latvia Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3585-5733","authenticated-orcid":false,"given":"Javier","family":"Tejedor\u2010Tejada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital Universitario de Cabue\u00f1es Gij\u00f3n Asturias Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6486-1262","authenticated-orcid":false,"given":"Jose M.","family":"Huguet","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital General Universitario de Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galyna","family":"Fadieienko","sequence":"additional","affiliation":[{"name":"Departments the Division for the Study of the Digestive Diseases and Its Comorbidity With Noncommunicable Diseases Government Institution L.T. 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