{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T04:46:58Z","timestamp":1782794818927,"version":"3.54.5"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Management of refractory\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Helicobacter pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      (\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      ) infection remains challenging due to increasing antibiotic resistance and limited effective rescue options. Minocycline and furazolidone retain low resistance rates, while potassium\u2010competitive acid blockers (P\u2010CABs) provide potent and sustained acid suppression. This study aimed to evaluate the efficacy and safety of a 14\u2010day P\u2010CAB\u2010based regimen combining minocycline, furazolidone, and bismuth in patients with refractory\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      From January 2023 to October 2025, clinical data were collected from patients with refractory\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection who received the above regimen at Tongji Hospital, Wuhan, China. Eradication was assessed by a urea breath test performed at least 4\u2009weeks after treatment. Adverse events during treatment were recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 368 patients were included in modified intention\u2010to\u2010treat analysis. Of them, 183 (49.7%) had two previous eradication failures, 165 (44.8%) had three to four failures, and 20 (5.4%) had five or more failures. Among the 143 patients who underwent antibiotic resistance gene testing, the resistance rates to clarithromycin and quinolones were 96.5% and 79.7%, respectively. The\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      eradication rate was 92.7% (95% CI 89.5%\u201394.9%) in modified intention\u2010to\u2010treat analysis and 96.4% (95% CI 93.8%\u201397.9%) in per\u2010protocol analysis. Adverse events occurred in 25.8% of patients and were predominantly mild to moderate, with dizziness (9.5%), nausea (5.2%), and abdominal distension (5.2%) most common. Poor compliance (OR\u2009=\u200918.14, 95% CI 6.39\u201351.51) and peptic ulcer (OR\u2009=\u20094.34, 95% CI 1.27\u201314.82) were independently associated with eradication failure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The 14\u2010day regimen of P\u2010CAB, minocycline, furazolidone, and bismuth is highly effective and well tolerated in patients with refractory\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection. This regimen represents a promising empirical rescue therapy, particularly in settings where antimicrobial susceptibility testing is unavailable.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.70128","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T08:45:47Z","timestamp":1778921147000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High Eradication Rate of a Potassium\u2010Competitive Acid Blocker\u2010Based Minocycline, Furazolidone, and Bismuth Regimen for Refractory\n                    <i>Helicobacter pylori<\/i>\n                    Infection: A Real\u2010World Study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0057-6575","authenticated-orcid":false,"given":"Ji\u2010Yan","family":"Li","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Ying","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Pharmacy Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Mei","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan 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