{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T15:51:41Z","timestamp":1788105101720,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100020209","name":"Shaanxi Provincial Health Commission","doi-asserted-by":"publisher","award":["2024TD\u201006"],"award-info":[{"award-number":["2024TD\u201006"]}],"id":[{"id":"10.13039\/501100020209","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2025ZD0545301"],"award-info":[{"award-number":["2025ZD0545301"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Vonoprazan\u2010based dual therapy has been proposed as a simplified strategy for\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Helicobacter pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      eradication, but head\u2010to\u2010head comparisons of different antibiotic partners are limited. We compared the efficacy, safety, and adherence of vonoprazan\u2010based dual regimens with those of bismuth\u2010containing quadruple therapy (BQT).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this randomized controlled trial,\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      \u2013infected patients were allocated (1:1:1:1) to receive VA (vonoprazan [20\u2009mg, bid] plus amoxicillin [1000\u2009mg, tid]), VT (vonoprazan [20\u2009mg, bid] plus tetracycline [500\u2009mg, tid]), VM (vonoprazan [20\u2009mg, bid] plus minocycline [100\u2009mg, bid]), or VACB (vonoprazan [20\u2009mg, bid], amoxicillin [1000\u2009mg, bid], clarithromycin [500\u2009mg, bid], and bismuth [220\u2009mg, bid]) for 14\u2009days. The primary endpoint was the\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      eradication rate, and the secondary endpoints were the incidence of adverse events and patient adherence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The ITT eradication rates were 83.0% (83\/100), 74.0% (74\/100), 82.0% (82\/100), and 83.0% (83\/100) in the VA, VT, VM, and VACB groups, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.304). The PP eradication rates were 90.2% (83\/92), 83.1% (74\/89), 88.2% (82\/93), and 92.2% (83\/90), respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.262). Adverse events occurred in 21.5% of the patients overall and differed across groups (10.0%, 15.0%, 29.0%, and 32.0% in VA, VT, VM, and VACB, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001); nausea and dizziness were more frequent with VM, whereas bitter taste and black stool were more frequent with VACB. All adverse events were mild or moderate, and no severe events were recorded. Adherence was high and comparable across groups (VA 100.0%, VT 96.0%, VM 99.0%, VACB 99.0%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.107).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vonoprazan\u2010based regimens showed no statistically significant between\u2010group differences in eradication and were associated with good adherence overall. In our setting, VA and VM may represent practical simplified options, whereas VT appeared less robust as an empiric regimen. These exploratory findings warrant confirmation in larger, adequately powered randomized trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      (NCT07068607)\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.70132","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T08:54:21Z","timestamp":1778921661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and Safety of Vonoprazan\u2010Based Dual Therapies With Different Antibiotics Versus Bismuth\u2010Containing Quadruple Therapy for\n                    <scp>\n                      <i>Helicobacter pylori<\/i>\n                    <\/scp>\n                    Eradication: A Prospective, Four\u2010Arm, Randomized Controlled Trial"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7013-3115","authenticated-orcid":false,"given":"Jie","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases Fourth Military Medical University  Xi'an China"},{"name":"Postgraduate Department Xi'an Medical University  Xi'an Shaanxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deng\u2010Hua","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi\u2010Qi","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases Fourth Military Medical University  Xi'an China"},{"name":"Postgraduate Department Xi'an Medical University  Xi'an Shaanxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology  Pingdingshan Henan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Jing","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Hao","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3004-2634","authenticated-orcid":false,"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9515-7577","authenticated-orcid":false,"given":"Yong\u2010Quan","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases Fourth Military Medical University  Xi'an 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