{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T04:47:05Z","timestamp":1782794825118,"version":"3.54.5"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260118"],"award-info":[{"award-number":["82260118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background and Aims<\/jats:title>\n \n \n Helicobacter pylori<\/jats:italic>\n <\/jats:styled-content>\n is a persistent gastric microbe with systemic consequences beyond the stomach, yet its contribution to host lipid dysregulation remains unclear.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We analyzed clinical data from 57,295 adults with documented\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n status and detailed lipid profiles, including the non\u2013HDL\u2010C to HDL\u2010C ratio (NHHR). Mechanistic validation was performed using in\u00a0vitro and in\u00a0vivo\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n PMSS1 infection models, combined with single\u2010cell RNA sequencing, molecular analyses, histopathology, and lipidomics.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n \n Helicobacter pylori<\/jats:italic>\n <\/jats:styled-content>\n infection was associated with increased LDL cholesterol and triglycerides, reduced HDL cholesterol, and elevated NHHR, which independently predicted hyperlipidemia risk. At the mechanistic level,\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n infection consistently suppressed gastric expression of Gpihbp1, a key mediator of lipoprotein lipase\u2013dependent lipid transport. Infected mice developed systemic hyperlipidemia and exhibited lipidomic remodeling characterized by glycerolipid accumulation and reduced phosphatidylcholine species. Importantly, genetic deficiency of\n Gpihbp1<\/jats:italic>\n promoted gastric\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n colonization and exacerbated mucosal inflammation, revealing a reciprocal interaction between host lipid metabolism and bacterial persistence.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n These findings define a microbiota\u2013host lipid transport axis linking chronic\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n infection to dyslipidemia and suggest that integrated targeting of microbial infection and metabolic dysfunction may offer therapeutic benefit.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/hel.70135","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T08:47:52Z","timestamp":1778921272000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Bidirectional Association Between\n Helicobacter pylori<\/i>\n Infection and Hyperlipidemia: Clinical Evidence and Mechanistic Insights"],"prefix":"10.1111","volume":"31","author":[{"given":"Yan'an","family":"Zhou","sequence":"first","affiliation":[{"name":"Jiangxi Provincial Key Laboratory of Digestive Diseases, Department of Gastroenterology, Digestive Disease Hospital The First Affiliated Hospital, Jiangxi Medical College, Nanchang University Nanchang Jiangxi China"},{"name":"Department of Cardiology The First Affiliated Hospital, Jiangxi Medical College, Nanchang University Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Key Laboratory of Digestive Diseases, Department of Gastroenterology, Digestive Disease Hospital The First Affiliated Hospital, Jiangxi Medical College, Nanchang University Nanchang Jiangxi China"},{"name":"Huankui Academy, Nanchang University Nanchang Jiangxi 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