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Beyond its established role in gastritis, peptic ulcer disease, and gastric adenocarcinoma, accumulating evidence implicates\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    in a spectrum of hematologic disorders. Iron deficiency anemia (IDA), vitamin B12 deficiency, immune thrombocytopenic purpura (ITP), and gastric mucosa\u2010associated lymphoid tissue (MALT) lymphoma represent the most substantiated associations. Pathogenesis is multifactorial, encompassing chronic inflammation, cytokine dysregulation, molecular mimicry, impaired micronutrient absorption, and virulence factor\u2010mediated disruption of host cellular processes, notably through CagA, VacA, SabA, and BabA components. In IDA and vitamin B12 deficiency,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    \u2010induced hypochlorhydria, altered gastric ascorbate levels, and hepcidin upregulation compromise systemic iron and cobalamin homeostasis. In contrast, in ITP, cross\u2010reactivity between bacterial antigens and platelet epitopes triggers the production of autoantibodies and accelerates platelet clearance. Chronic antigenic stimulation and epigenetic modifications underpin lymphomagenesis in gastric MALT lymphoma, with treatment response modulated by strain\u2010specific virulence, host genetics, and somatic translocations affecting NF\u2010\u03baB signaling. Clinical evidence demonstrates that targeted eradication therapy, often in combination with micronutrient supplementation, significantly restores hematologic parameters and mitigates systemic sequelae, yet patient\u2010specific variability necessitates individualized management strategies. This review integrates current mechanistic and clinical insights into\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    \u2010associated hematologic manifestations, highlighting the bacterium's systemic impact, elucidating therapeutic implications, and identifying critical gaps for future research aimed at optimizing diagnostic precision, intervention efficacy, and prognostic outcomes in affected populations.\n                  <\/jats:p>","DOI":"10.1111\/hel.70136","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T08:52:15Z","timestamp":1778921535000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Elucidating the Pathogenic Role of\n                    <i>Helicobacter pylori<\/i>\n                    Infection in Hematologic Disorders: Mechanistic Insights and Future Perspectives"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4672-0640","authenticated-orcid":false,"given":"Kimia","family":"Fathalizade","sequence":"first","affiliation":[{"name":"Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3109-3313","authenticated-orcid":false,"given":"Fattaneh","family":"Sabzehali","sequence":"additional","affiliation":[{"name":"Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases Shahid Beheshti University of Medical Sciences  Tehran 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