{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:27:42Z","timestamp":1791779262661,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Our previous randomized controlled trial reported that\n \n Helicobacter pylori<\/jats:italic>\n <\/jats:styled-content>\n eradication reduced the risk of metachronous gastric cancer over a median follow\u2010up of 5.9\u2009years in patients with early gastric cancer (EGC) and improved corpus gastric atrophy (GA) at the specific 3\u2009year follow\u2010up time. This study aimed to evaluate the long\u2010term effects of\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n eradication on GA and intestinal metaplasia (IM) at trial closeout.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Among 470 patients randomized between 2003 and 2013, 327 who were assessed for GA and IM at both baseline and 3\u2010year follow\u2010up time were included in the study. At trial closeout,\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n status, GA, and IM were assessed. Main outcomes were improvement in GA and IM at the corpus lesser curvature (LC) according to the\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n status at the closeout time. The secondary outcomes included the Operative Link for Gastritis Assessment (OLGA) and Operative Link for Gastric Intestinal Metaplasia assessment (OLGIM) stage improvements.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n At a median follow\u2010up of 5.9\u2009years (interquartile range: 4.0\u20138.2\u2009years), an improvement in\n GA<\/jats:styled-content>\n grades at the corpus\n LC<\/jats:styled-content>\n was observed in 88 of the 150 patients (58.7%) in the\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n \u2010eradicated group and 31 of the 158 patients (19.6%) in the\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n \u2010persistent group (odds ratio [\n OR<\/jats:styled-content>\n ] in the\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n \u2010eradicated group, 5.81; 95% confidence interval [\n CI<\/jats:styled-content>\n ], 3.49\u20139.68).\n IM<\/jats:styled-content>\n grades showed greater improvement in the\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n \u2010eradicated group (42.4% [67\/158 patients]) compared with the\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n \u2010persistent group (18.6% [31\/167 patients]);\n OR<\/jats:styled-content>\n in the eradicated group (3.23; 95%\n CI<\/jats:styled-content>\n , 1.96\u20135.33). Similarly, the\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n \u2010eradicated group exhibited significantly higher rates of improvement in both\n OLGA<\/jats:styled-content>\n (\n OR<\/jats:styled-content>\n 6.48; 95%\n CI<\/jats:styled-content>\n , 3.85\u201310.91) and\n OLGIM<\/jats:styled-content>\n stages (\n OR<\/jats:styled-content>\n 2.31; 95%\n CI<\/jats:styled-content>\n , 1.42\u20133.77).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In patients with EGC who have far advanced histologic changes in the background mucosa,\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n eradication was associated with a significant improvement in GA and IM.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/hel.70139","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T08:49:38Z","timestamp":1778921378000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010Term Effect of\n \n Helicobacter pylori<\/i>\n <\/scp>\n Eradication on Gastric Atrophy and Intestinal Metaplasia After Endoscopic Resection of Gastric Neoplasm: A Follow\u2010Up of a Randomized Controlled Trial"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2614-3419","authenticated-orcid":false,"given":"Young\u2010Il","family":"Kim","sequence":"first","affiliation":[{"name":"Center for Gastric Cancer National Cancer Center Goyang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8709-5097","authenticated-orcid":false,"given":"Jong Yeul","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Gastric Cancer National Cancer Center Goyang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1651-2559","authenticated-orcid":false,"given":"Chan Gyoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Gastric Cancer National Cancer Center Goyang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3435-3301","authenticated-orcid":false,"given":"Myeong\u2010Cherl","family":"Kook","sequence":"additional","affiliation":[{"name":"Center for Gastric Cancer National Cancer Center Goyang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2683-8795","authenticated-orcid":false,"given":"Boram","family":"Park","sequence":"additional","affiliation":[{"name":"College of Medicine Inha University Incheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8339-9824","authenticated-orcid":false,"given":"Il Ju","family":"Choi","sequence":"additional","affiliation":[{"name":"Center for Gastric Cancer National Cancer Center Goyang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,16]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"3554","article-title":"A Human Model of Gastric Carcinogenesis","volume":"48","author":"Correa P.","year":"1988","journal-title":"Cancer 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