{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:19:18Z","timestamp":1788149958497,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2026,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n \n Helicobacter pylori<\/jats:italic>\n <\/jats:styled-content>\n (Hp) infection is the primary risk factor for gastric cancer, yet the consequences of the infection vary by bacterial and host factors. The outer membrane protein HopQ plays a key role in Hp adhesion, but its genetic diversity and clinical implications are unclear. HopQ\u2013CEACAM interaction facilitates the translocation of the cytotoxin\u2010associated gene A (CagA).\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n We analyzed\n hopQ<\/jats:italic>\n sequences from 1038 Hp strains, mainly from the\n \n Helicobacter pylori<\/jats:italic>\n <\/jats:styled-content>\n Genome Project, integrating phylogenetic, genotypic, and disease association analyses. Logistic regression models assessed the association between\n hopQ<\/jats:italic>\n genotypes and disease, accounting for\n cagA<\/jats:italic>\n status and Hp ancestry.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n hopQ<\/jats:italic>\n genotypes have a strong population structure. The hpAfrica1 and hpNorthAsia (including hspIndigenousAmerica) populations exhibited distinct\n hopQ<\/jats:italic>\n patterns, suggesting ancestry\u2010specific pathogenicity.\n hopQ<\/jats:italic>\n genotypes were classified as\n hopQI<\/jats:italic>\n and\n hopQII<\/jats:italic>\n ;\n hopQI<\/jats:italic>\n was further divided into high\u2010risk and low\u2010risk variants. Ancestry\u2010adjusted analyses showed that\n hopQI<\/jats:italic>\n high\u2010risk was associated (odds ratio\u2009=\u20093.1;\n p<\/jats:italic>\n \u2009<\u20090.0001) with advanced disease (intestinal metaplasia and gastric cancer combined vs. non\u2010atrophic gastritis), independently of\n cagA<\/jats:italic>\n . In contrast,\n hopQII<\/jats:italic>\n and\n hopQI<\/jats:italic>\n low\u2010risk variants correlated with a reduced risk.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The\n hopQ<\/jats:italic>\n diversity is a key determinant of Hp pathogenicity.\n hopQI<\/jats:italic>\n high\u2010risk is a predictor of advanced disease, whereas\n hopQII<\/jats:italic>\n and\n hopQI<\/jats:italic>\n low\u2010risk may be protective. Understanding\n hopQ<\/jats:italic>\n variability could improve risk stratification and the targeted therapies for gastric cancer.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/hel.70145","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:22:34Z","timestamp":1783056154000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Worldwide Phylogenetic and Clinical Risk Association of the\n \n Helicobacter pylori<\/i>\n <\/scp>\n Outer Membrane Gene\n \n hopQ<\/i>\n <\/scp>"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8653-3320","authenticated-orcid":false,"given":"Edson I.","family":"Rubio\u2010Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Virolog\u00eda y C\u00e1ncer Hospital Infantil de M\u00e9xico Federico G\u00f3mez Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezequiel M.","family":"Fuentes\u2010Panan\u00e1","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Virolog\u00eda y C\u00e1ncer Hospital Infantil de M\u00e9xico Federico G\u00f3mez Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaisa","family":"Thorell","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Molecular Biology, Faculty of Science and Technology University of Gothenburg Gothenburg Sweden"},{"name":"Science for Life Laboratory, (SciLifeLab) University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonne","family":"Nasimiyu","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville Maryland USA"},{"name":"Department of Biology Hood College Frederick Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith","family":"Yeager","sequence":"additional","affiliation":[{"name":"Department of Biology Hood College Frederick Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6990-9114","authenticated-orcid":false,"given":"Roberto C.","family":"Torres","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Enfermedades Infecciosas UMAE Pediatr\u00eda, Instituto Mexicano del Seguro Social Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Luo","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville Maryland USA"},{"name":"Cancer Genomics Research Laboratory Frederick National Laboratory for Cancer Research Frederick Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Difei","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville Maryland USA"},{"name":"Cancer Genomics Research Laboratory Frederick National Laboratory for Cancer Research Frederick Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Constanza","family":"Camargo","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Torres","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Enfermedades Infecciosas UMAE Pediatr\u00eda, Instituto Mexicano del Seguro Social Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8673-0191","authenticated-orcid":false,"given":"Zilia Y.","family":"Mu\u00f1oz\u2010Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Qu\u00edmicas Universidad Aut\u00f3noma de Chihuahua Chihuahua Chihuahua 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