{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T04:46:57Z","timestamp":1782794817586,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Resistance to antibiotics has resulted in the effectiveness of conventional eradication therapies for\n \n Helicobacter pylori<\/jats:italic>\n <\/jats:styled-content>\n being reduced, creating a need for regimens that are effective, safe, and simple. In this study, we evaluated the eradication efficacy, adverse events, and medication adherence of four different tegoprazan\u2010based regimens administered as first\u2010line therapy for\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n infection. We also explored the clinical value of adding bismuth to a triple therapy regimen.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In this prospective, randomized controlled trial, 640 treatment\u2010naive patients with confirmed\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n infection were randomly assigned to one of the four groups undergoing 14\u2010day treatment regimens of tegoprazan\u2013amoxicillin (TA), tegoprazan\u2013tetracycline (TT), tegoprazan\u2013amoxicillin\u2013tetracycline (TAT), or tegoprazan\u2013amoxicillin\u2013tetracycline\u2013bismuth (TATB), with 160 patients in each group. The outcomes were the eradication rate, incidence of adverse events, and medication adherence.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In the intention\u2010to\u2010treat analysis, the\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n eradication rates in the TA, TT, TAT, and TATB groups were 80.0% (95% confidence interval [CI]: 73.0\u201385.9), 61.9% (95% CI: 53.9\u201369.4), 93.1% (95% CI: 88.0\u201396.5), and 89.4% (95% CI: 83.5\u201393.7), respectively. Compared with the TATB regimen, the TAT regimen was non\u2010inferior (95% CI, \u22123.9% to 11.5%; non\u2010inferiority\n p<\/jats:italic>\n \u2009<\u20090.001), whereas demonstrating non\u2010inferiority in the TA and TT regimens failed. Adverse events were less frequent in the TA (10.6%), TT (17.5%), and TAT (20.0%) groups than in the TATB group (36.9%; all\n p<\/jats:italic>\n \u2009<\u20090.001). Medication adherence was high across groups, with no significant between\u2010group differences observed.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n High eradication efficacy was demonstrated for the TAT regimen; this regimen was non\u2010inferior to the TATB regimen, and it was associated with fewer adverse events. These findings suggest that it may be an effective first\u2010line treatment option for\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n infection.\n <\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n ClinicalTrials.gov<\/jats:ext-link>\n identifier: NCT06977841\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/hel.70147","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T04:51:23Z","timestamp":1781239883000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Tegoprazan\u2010Based Dual, Triple, and Quadruple Therapies in First\u2010Line\n \n Helicobacter pylori<\/i>\n <\/scp>\n Eradication: A Prospective Randomized Controlled Trial"],"prefix":"10.1111","volume":"31","author":[{"given":"Yu\u2010Cheng","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Zhongshan Hospital (Xiamen), Fudan University Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Zhongshan Hospital (Xiamen), Fudan University Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjiang","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Cancer Research Center, School of Medicine, Faculty of Medicine and Life Sciences Xiamen University Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihui","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Zhongshan Hospital (Xiamen), Fudan University Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Zhongshan Hospital (Xiamen), Fudan University Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Meng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, School of Public Health Xiamen University Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xia","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Cancer Research Center, School of Medicine, Faculty of Medicine and Life Sciences Xiamen University Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Zhongshan Hospital, Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress 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