{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:00:40Z","timestamp":1792479640550,"version":"4.5.0"},"reference-count":178,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Aims<\/jats:title>\n                    <jats:p>\n                      Since the 2020 Korean guidelines for\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Helicobacter pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      treatment, clarithromycin resistance rates have risen from 17.8% to 33.3%, dual\u2010priming oligonucleotide\u2010based polymerase chain reaction (DPO\u2010PCR)\u2010based tailored therapy has been adopted, and P\u2010CABs have become available. This fourth revision addresses these changes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Nine key questions were addressed through systematic reviews with meta\u2010analyses. Thirteen recommendations were evaluated via modified Delphi process involving 64 experts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twelve recommendations achieved first\u2010round consensus; one required revision and achieved 73.9% agreement. Key changes: (1) dual\u2010pillar strategy of tailored therapy and empirical quadruple therapy; (2) restricted use of empirical clarithromycin\u2010based triple therapy under specific conditions; (3) removal of sequential therapy; (4) P\u2010CABs as PPI alternatives; (5) expansion of eradication indications to include gastric cancer prevention in\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H.\u2009pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      gastritis and regression of hyperplastic polyps \u2264\u200910\u2009mm; and (6) positioning of bismuth quadruple therapy as a conditionally recommended first\u2010line empirical option with preference for reservation as salvage therapy, and introduction of modified bismuth quadruple therapy (addition of bismuth to conventional regimens) as an additional first\u2010line empirical option.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This fourth revised guideline provides updated, evidence\u2010based recommendations for the diagnosis and treatment of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H.\u2009pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection, reflecting the rapidly changing antibiotic resistance landscape and the introduction of new diagnostic and therapeutic tools in Korea. These guidelines aim to assist clinicians, patients, policymakers, and medical educators in optimizing\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H.\u2009pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      management. They may differ from current medical insurance standards and will be revised further based on emerging evidence.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.70149","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:36:33Z","timestamp":1783946193000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evidence\u2010Based Guidelines for the Diagnosis and Treatment of\n                    <i>Helicobacter pylori<\/i>\n                    Infection in Korea: 2025 Revised Edition"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4908-5431","authenticated-orcid":false,"given":"Chang Seok","family":"Bang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Hallym University College of Medicine  Chuncheon 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