{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:19:11Z","timestamp":1788149951540,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      This study aimed to investigate the current knowledge, attitudes, and practices of Chinese physicians regarding the management of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Helicobacter pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection through a large\u2010scale national survey.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      This national, multicenter cross\u2010sectional survey was conducted from October 2024 to May 2025 among physicians from over 2200 medical institutions across 31 provinces using an online questionnaire. The survey comprised four dimensions: basic information, knowledge, attitudes, and practices. Results were compared with the Sixth Chinese National Consensus Report on the Management of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection and the Maastricht VI\/Florence guidelines. Further, subgroup analyzes were conducted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 6030 valid responses were included.\n                      <jats:italic>Knowledge<\/jats:italic>\n                      : Only 27.5% of participants correctly estimated the\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection rate as 40%\u201350%, and 13.5% accurately understood the reinfection rate as 2%.\n                      <jats:italic>Attitude<\/jats:italic>\n                      : Overall, 93.4% of participants reported familiarity with Chinese\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      guidelines and consensus statements, and 84.1% supported replacing proton pump inhibitors with potassium\u2010competitive acid blockers.\n                      <jats:italic>Practice<\/jats:italic>\n                      : Gaps were observed in recognizing indications for\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      eradication, including unexplained iron deficiency anemia (43.9%), primary immune thrombocytopenia (39.6%), vitamin B12 deficiency (32.3%), and\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection without countervailing factors (36.8%). The bismuth\u2010based quadruple regimen was the most commonly selected first\u2010line treatment (86.7%); however, 74.5% still selected the amoxicillin + clarithromycin combination, despite the high resistance rate associated with clarithromycin. The dual regimen is gradually gaining acceptance (53.9%).\n                      <jats:italic>Subgroup analyzes<\/jats:italic>\n                      : Greater adherence to guideline recommendations was observed among physicians from higher\u2010level medical institutions, gastroenterologists, those with more years of practice, higher professional titles, and educational levels, as well as those practicing in economically developed regions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Chinese physicians generally follow guideline\u2010recommended core practices for the diagnosis and treatment of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      . However, notable gaps persist in understanding reinfection rates, identifying appropriate eradication indications, and selecting optimal treatment regimens. Therefore, strengthened educational interventions are warranted.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.70151","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:36:33Z","timestamp":1783398993000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Current Status of Diagnosis, Treatment, and Prevention of\n                    <i>Helicobacter pylori<\/i>\n                    Infection in China: A 2024\u20132025 National Multicenter Cross\u2010Sectional Study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6456-3994","authenticated-orcid":false,"given":"Zhihao","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing 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Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3209-8105","authenticated-orcid":false,"given":"Yiling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Hospital of China Medical University  Shenyang Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0175-1837","authenticated-orcid":false,"given":"Xuehong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qinghai University Affiliated Hospital  Xining China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9232-7910","authenticated-orcid":false,"given":"Chunhui","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Daping Hospital Army Medical University (Third Military Medical University)  Chongqing 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