{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:19:16Z","timestamp":1788149956179,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":50,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Rescue treatment for\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Helicobacter pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection remains challenging in regions with high antibiotic resistance. Although bismuth\u2010containing quadruple therapy is widely recommended as an empirical rescue regimen, its medication burden may impair tolerability and adherence. This trial evaluated the efficacy and safety of 14\u2010day vonoprazan\u2013minocycline dual therapy compared with vonoprazan\u2010based bismuth\u2010containing quadruple therapy as empirical rescue treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      This single\u2010center, prospective, open\u2010label, randomized, controlled, noninferiority trial enrolled 186 adults aged 18\u201370\u2009years with at least one previous\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      eradication failure. Patients were randomly assigned (1:1) to receive 14\u2010day vonoprazan\u2013minocycline dual therapy or vonoprazan\u2010, amoxicillin\u2010, minocycline\u2010, and bismuth\u2010containing quadruple therapy. Eradication was assessed by a\n                      <jats:sup>13<\/jats:sup>\n                      C urea breath test 4\u2009weeks after treatment. ITT, mITT, and PP analyses were performed, with a prespecified noninferiority margin of \u221210%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eradication rates in the dual therapy and quadruple therapy groups were 89.2% and 91.4% in the ITT analysis (difference, \u22122.2%; 95% CI, \u221210.5% to 6.2%; noninferiority\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036), 90.2% and 92.4% in the mITT analysis (difference, \u22122.2%; 95% CI, \u22129.7% to 5.3%; noninferiority\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030), and 91.2% and 93.4% in the PP analysis (difference, \u22122.2%; 95% CI, \u22129.4% to 5.0%; noninferiority\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024). Noninferiority was demonstrated in the mITT and PP analyses, whereas the ITT result should be interpreted cautiously because the lower 95% CI bound crossed the margin. Adverse events were similar between treatment groups (11.8% vs. 15.1%;\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.416;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.519), and adherence was high in both groups (97.8% vs. 97.8%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.000).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      14\u2010day vonoprazan\u2013minocycline dual therapy achieved eradication rates comparable to those of bismuth\u2010containing quadruple therapy, with acceptable safety and high adherence as rescue treatment for\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection. This simplified regimen may be considered a potential empirical rescue option when susceptibility testing is not readily available, although the ITT noninferiority result warrants cautious interpretation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.70153","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T12:36:37Z","timestamp":1787229397000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["14\u2010Day Vonoprazan\u2013Minocycline Dual Therapy Versus Bismuth\u2010Containing Quadruple Therapy for\n                    <i>Helicobacter pylori<\/i>\n                    Rescue Treatment: A Single\u2010Center Randomized Controlled Noninferiority Trial"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2078-8965","authenticated-orcid":false,"given":"Tingting","family":"Yang","sequence":"first","affiliation":[{"name":"The Third Clinical Medical College Ningxia Medical University  Yinchuan China"},{"name":"Department of Gastroenterology, People's Hospital of Ningxia Hui Autonomous Region Affiliated People's Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijuan","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, People's Hospital of Ningxia Hui Autonomous Region Affiliated People's Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, People's Hospital of Ningxia Hui Autonomous Region Affiliated People's Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, People's Hospital of Ningxia Hui Autonomous Region Affiliated People's Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, People's Hospital of Ningxia Hui Autonomous Region Affiliated People's Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2397-2930","authenticated-orcid":false,"given":"Xiaole","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, People's Hospital of Ningxia Hui Autonomous Region Affiliated People's Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linke","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, People's Hospital of Ningxia Hui Autonomous Region Affiliated People's Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6676-8800","authenticated-orcid":false,"given":"Xiaoming","family":"Su","sequence":"additional","affiliation":[{"name":"The Third Clinical Medical College Ningxia Medical University  Yinchuan China"},{"name":"Department of Gastroenterology, People's Hospital of Ningxia Hui Autonomous Region Affiliated People's Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3237-7242","authenticated-orcid":false,"given":"Yanxia","family":"Liu","sequence":"additional","affiliation":[{"name":"The Third Clinical Medical College Ningxia Medical University  Yinchuan China"},{"name":"Department of Gastroenterology, People's Hospital of Ningxia Hui Autonomous Region Affiliated People's Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengdong","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, People's Hospital of Ningxia Hui Autonomous Region Affiliated People's Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, People's Hospital of Ningxia Hui Autonomous Region Affiliated People's Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, People's Hospital of Ningxia Hui Autonomous Region Affiliated People's Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, People's Hospital of Ningxia Hui Autonomous Region Affiliated People's Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengda","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, People's Hospital of Ningxia Hui Autonomous Region Affiliated People's Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, People's Hospital of Ningxia Hui Autonomous Region Affiliated People's Hospital of Ningxia Medical University  Yinchuan 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