{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:19:16Z","timestamp":1788149956504,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":40,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To evaluate the diagnostic accuracy in\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Helicobacter pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      detection using blood test with FliD and CagA antibodies (Pylori DuoTect), comparing with rapid urease test (RUT) and urease breath test (UBT) in Vietnamese patients with upper GI symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cross\u2010sectional study was conducted at the Institute of Gastroenterology and Hepatology in Hanoi, Vietnam on adults with upper GI symptoms, no prior treatment of peptic ulcers, and no history of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection. Participants underwent upper GI endoscopy and three\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      tests, including rapid urease test (RUT), urea breath test (UBT), and Pylori DuoTect. Pylori DuoTect was considered positive if either FliD or CagA antibodies were detected. The\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection was defined as both RUT and UBT positive. Endoscopic findings were classified using the Kyoto classification score for gastritis. Diagnostic accuracy was evaluated using sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From December 1, 2023, to August 9, 2024, 333 patients were recruited (mean age 45.9\u2009years, 39.9% male). The most common symptom was epigastric pain (49.5%). The prevalences of gastritis, gastric ulcers, and duodenal ulcers were 92.7%, 12.1%, and 8.1%, respectively. Pylori DuoTect was positive in 51.9% of patients (FliD: 34.8% and CagA: 66.6%). Using the gold standard, 33.6% were diagnosed with\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection. The sensitivity, specificity, PPV, and NPV of Pylori DuoTect were 83.0%, 64.0%, 54.0%, and 88.0%, respectively. Combining Pylori DuoTect and endoscopy findings (peptic ulcer or Kyoto score\u2009\u2265\u20092) improved the sensitivity from 0.83 to 0.88 and increased NPV.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Pylori DuoTect had moderate sensitivity and low specificity in the diagnosis of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection in Vietnamese adult patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.70155","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T05:17:37Z","timestamp":1786425457000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Value of the Pylori DuoTect Test for\n                    <i>Helicobacter pylori<\/i>\n                    Detection in the Vietnamese Population"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3685-9496","authenticated-orcid":false,"given":"Hang Dao","family":"Viet","sequence":"first","affiliation":[{"name":"Internal Medicine Faculty Hanoi Medical University  Hanoi Vietnam"},{"name":"Institute of Gastroenterology and Hepatology  Hanoi Vietnam"},{"name":"Endoscopy Centre Hanoi Medical University Hospital  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3572-9235","authenticated-orcid":false,"given":"Binh Nguyen","family":"Phuc","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology and Hepatology  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6039-4273","authenticated-orcid":false,"given":"Thao Dang","family":"Thi","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology and Hepatology  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0453-0426","authenticated-orcid":false,"given":"Trang Nguyen Thi","family":"Huyen","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology and Hepatology  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4112-7990","authenticated-orcid":false,"given":"Thuong Nguyen","family":"Thu","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology and Hepatology  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6193-9403","authenticated-orcid":false,"given":"Uyen Vu Thi","family":"Thu","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology and Hepatology  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2829-3875","authenticated-orcid":false,"given":"Long Hoang","family":"Bao","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology and Hepatology  Hanoi Vietnam"},{"name":"College of Health Sciences VinUniversity  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7162-9557","authenticated-orcid":false,"given":"Long Dao","family":"Van","sequence":"additional","affiliation":[{"name":"Internal Medicine Faculty Hanoi Medical University  Hanoi Vietnam"},{"name":"Institute of Gastroenterology and Hepatology  Hanoi Vietnam"},{"name":"Endoscopy Centre Hanoi Medical University Hospital  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"1","article-title":"Schistosomes, Liver Flukes and \n                     Helicobacter pylori","volume":"61","author":"IARC Lyon","year":"1994","journal-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0260454"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70122-8"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i45.8219"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37095-4"},{"key":"e_1_2_11_7_1","first-page":"13","article-title":"The Prevalence of the CagAgene of Helicobacter Pylori and Its Association With Gastroduodenal Diseases","volume":"67","author":"Nhung T. 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